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Titolo:
STABILITY OF ALVEOLAR-CAPILLARY OPENING PRESSURES
Autore:
PRESSON RG; OKADA O; HANGER CC; GODBEY PS; GRAHAM JA; GLENNY RW; CAPEN RL; WAGNER WW;
Indirizzi:
JAMES WHITCOMB RILEY HOSP CHILDREN,702 BARNHILL DR,RM 2001 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT ANESTHESIA INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PHYSIOL & BIOPHYS INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT PEDIAT INDIANAPOLIS IN 46202 CHIBA UNIV,SCH MED,DEPT CHEST MED CHIBA 280 JAPAN UNIV WASHINGTON,DEPT MED,DIV PULM & CRIT CARE MED SEATTLE WA 98195 COLORADO COLL,DEPT BIOL COLORADO SPRINGS CO 80903
Titolo Testata:
Journal of applied physiology
fascicolo: 4, volume: 77, anno: 1994,
pagine: 1630 - 1637
SICI:
8750-7587(1994)77:4<1630:SOAOP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTROPHIL KINETICS; DOG LUNG; RECRUITMENT; WALLS; FLOW;
Keywords:
CAPILLARY PERFUSION PATTERNS; CAPILLARY RECRUITMENT; ISOLATED CANINE LUNG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Presson et al., "STABILITY OF ALVEOLAR-CAPILLARY OPENING PRESSURES", Journal of applied physiology, 77(4), 1994, pp. 1630-1637

Abstract

Little is known about the stability of the process by which pulmonarycapillaries open. To investigate this process, pulmonary capillary perfusion patterns in isolated pump-perfused canine lobes were studied using video microscopy. After pump flow was set to perfuse one-half of the capillaries, the pump was turned off and all of the capillaries emptied. Turning the pump back on reopened the capillaries. The on-off cycle was repeated six times. If the same capillaries were perfused during each observation, it would demonstrate that there were stable and significant differences between individual capillary opening pressures, causing consistent recruitment of those capillaries with the lowest opening pressures. Alternatively, variable perfusion patterns would result if capillary opening pressures changed between observations, if the differences in opening pressures between capillary segments were negligible, or if experimental conditions changed between cycles. The perfusion pattern was more reproducible than expected by chance alone, which indicated the existence of stable differences among alveolar capillary opening pressures.

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Documento generato il 11/07/20 alle ore 09:39:14