Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Expression and distribution of CYP2C enzymes in rat basal ganglia
Autore:
Riedl, AG; Watts, PM; Douek, DC; Edwards, RJ; Boobis, AR; Rose, S; Jenner, P;
Indirizzi:
Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, London WC2R 2LS, England Univ London Kings Coll London England WC2R 2LS London WC2R 2LS, England Hammersmith Hosp, Imperial Coll, Sch Med, MRC,Clin Sci Ctr,Transplantat Biol Grp, London, England Hammersmith Hosp London England ,Transplantat Biol Grp, London, England Hammersmith Hosp, Imperial Coll, Sch Med, Div Med,Sect Clin Pharmacol, London, England Hammersmith Hosp London England ed,Sect Clin Pharmacol, London, England
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 38, anno: 2000,
pagine: 392 - 402
SICI:
0887-4476(200012)38:4<392:EADOCE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; MPTP-INDUCED NEUROTOXICITY; DRUG-METABOLIZING-ENZYMES; PARKINSONS-DISEASE; LIVER-MICROSOMES; P450 ENZYMES; FEMALE RATS; CATECHOL ESTROGENS; CYTOCHROME-P-450; BRAIN;
Keywords:
brain; CYP2C13; immunohistochemistry; P450; Parkinson disease; neurosteroids; catecholoestrogens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Jenner, P Univ London Kings Coll, Guys Kings & St Thomas Sch Biomed Sci, Neurodegenerat Dis Res Ctr, Hodgkin Bldg, London WC2R 2LS, England Univ London Kings Coll Hodgkin Bldg London England WC2R 2LS and
Citazione:
A.G. Riedl et al., "Expression and distribution of CYP2C enzymes in rat basal ganglia", SYNAPSE, 38(4), 2000, pp. 392-402

Abstract

The function and integrity of the basal ganglia is modulated by sex steroids whose activity may be controlled by P450 enzymes, such as members of theCYP2C subfamily. The expression of CYP2C enzymes in rat basal ganglia was examined by immunohistochemistry along with some of the factors that might control their expression. Whereas no CYP2C11 or CYP2C12 immunoreactivity was detected in the basal ganglia of either male or female rats, marked CYP2C13 immunoreactivity was evident in neurones of the subthalamic nucleus, substantia nigra, and interpeduncular nucleus. Strong CYP2C13 immunoreactivitywas also expressed in the cortex, olfactory tubercle, hippocampus, dentategyrus, hypothalamic nuclei, medial habenular nucleus, red nucleus, and medial forebrain bundle. Similar results were found in male and female rats. Following 6-hydroxydopamine lesioning of the nigro-striatal tract, tyrosine hydroxylase immunoreactivity was absent and CYP2C13 immunoreactivity was decreased markedly in the substantia nigra pars compacta, implying its presence in dopaminergic neurones. Modulation of sex steroids, using castrated rats, had no effect on the number of CYP2C13 positive neurones in the substantia nigra pars compacta. These results indicate that CYP2C13 protein is constitutively and widely expressed in rat brain. However, its expression is not sex-specific and is unaffected by castration. The role of CYP2C13 in brain is unknown but it may be involved in the generation of neurosteroids andcatecholoestrogens. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:08:01