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Titolo:
Immunologic profiles of effector cells and peripheral blood stem cells mobilized with different hematopoietic growth factors
Autore:
Gazitt, Y;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Med Hematol, San Antonio, TX 78284 USA UnivTexas San Antonio TX USA 78284 ed Hematol, San Antonio, TX 78284 USA
Titolo Testata:
STEM CELLS
fascicolo: 6, volume: 18, anno: 2000,
pagine: 390 - 398
SICI:
1066-5099(2000)18:6<390:IPOECA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; FACTOR G-CSF; HIGH-DOSE CHEMOTHERAPY; NATURAL-KILLER-CELLS; RECOMBINANT HUMAN GRANULOCYTE; ADHESION MOLECULE EXPRESSION; MARROW CD34(+) CELLS; PROGENITOR CELLS; DENDRITIC CELLS; BONE-MARROW;
Keywords:
mobilization; CD34(+) cells; VLA-4; L-selectin; CXCR4;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Gazitt, Y Univ Texas, Hlth Sci Ctr, Dept Med Hematol, 7703 Floyd Curl Dr, San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 78284 USA
Citazione:
Y. Gazitt, "Immunologic profiles of effector cells and peripheral blood stem cells mobilized with different hematopoietic growth factors", STEM CELLS, 18(6), 2000, pp. 390-398

Abstract

Background, Peripheral blood stem cells (PBSC) have become the preferred source of stem cells for autologous transplantation because of the technicaladvantage and the shorter time to engraftment, Mobilization of CD34(+) cells into the peripheral blood can be achieved by the administration of G-CSFor GMCSF, or both, alone or in combination with chemotherapy, G-CSF and GM-CSF differ somewhat in the number and composition of CD34(+) cells and effector cells mobilized to the peripheral blood, However, the molecular mechanism underlying the release and engraftment of CD34(+) cells is poorly understood. Purpose. The purpose of this review is to give a recent update on the typeand immunological properties of effector cells and CD34(+) cells mobilizedby the different growth factors with emphasis on A) mobilization of T cells, natural killer cells, and dendritic cells; B) coexpression of adhesion molecules such as VLA-4 and L-selectin in mobilized PBSC collection, and C) coexpression of CXCR4-the receptor for the stromal-derived differentiation factor 1-with latest information shedding light on the molecular mechanism underlying the release and subsequent engraftment of CD34(+) cells. Conclusions. A) The reported suppression of T cell and NK cell functions in PBSC apheresis collections in patients primed with G-CSF or GM-CSF is controversial and may merely reflect low effector cell activity before mobilization, B) A decrease in the expression of adhesion molecules such as VLA-4 and L-selectin is a necessary requirement for the release of CD34(+) cells to the peripheral blood. C) A decrease in the expression of CXCR4 is a necessary requirement for the release of CD34(+) cells to the peripheral blood and correlates with mobilization success.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:43:55