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Titolo:
AUTOIMMUNE ENTEROPATHY AND VILLOUS ATROPHY IN ADULTS
Autore:
CORAZZA GR; BIAGI F; VOLTA U; ANDREANI ML; DEFRANCESCHI L; GASBARRINI G;
Indirizzi:
UNIV AQUILA,DEPT INTERNAL MED,VIA S SISTO 22E I-67100 LAQUILA ITALY UNIV BOLOGNA,DEPT INTERNAL MED BOLOGNA ITALY CATHOLIC UNIV ROME,DEPT INTERNAL MED ROME ITALY
Titolo Testata:
Lancet
fascicolo: 9071, volume: 350, anno: 1997,
pagine: 106 - 109
SICI:
0140-6736(1997)350:9071<106:AEAVAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPITHELIAL-CELL AUTOANTIBODIES; SMALL-INTESTINE; CELIAC-DISEASE; PROTRACTED DIARRHEA; SPRUE; ANTIBODY; PATHOGENESIS; JEJUNUM; INFANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
G.R. Corazza et al., "AUTOIMMUNE ENTEROPATHY AND VILLOUS ATROPHY IN ADULTS", Lancet, 350(9071), 1997, pp. 106-109

Abstract

Background Autoimmune enteropathy is a condition described in children and characterised by villous atrophy, which is unresponsive to any dietary restrictions, and by the presence of enterocyte autoantibodies. We report two adult patients who fulfilled all the criteria for the diagnosis of this disorder. Methods Over the past 5 years we have seen four adult patients (all women, median age 51.5 [range 38-64] years) with subtotal villous atrophy, which was unresponsive to a gluten-free diet. The patients were HLA-DQ2 positive. IgA antigliadin and antiendomysial antibodies were not found in any of the patients. We did an indirect immunofluorescence search for enterocyte autoantibodies on monkey jejunum and for other autoantibodies for all four patients. FindingsOf the four patients, two were positive for enterocyte autoantibodiesand one of these two patients was positive for antiactin, antiparietal cell, and antithyroid microsomal autoantibodies. Interpretation To the best of our knowledge the two patients affected by severe enteropathy, who had never responded to any exclusion diet, and who were positive for enterocyte autoantibodies are the first cases of autoimmune enteropathy described in adults. We propose that adult patients whose disorders are unresponsive to a gluten-free diet should be tested for enterocyte autoantibodies.

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Documento generato il 05/12/20 alle ore 13:19:53