Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SELEGILINE INDUCES DOPAMINE RELEASE THROUGH ATP-SENSITIVE POTASSIUM CHANNELS IN THE RAT CAUDATE-PUTAMEN IN-VITRO
Autore:
NEUSCH C; SCHNIERLE S; MOSER A;
Indirizzi:
UNIV LUBECK,DEPT NEUROL,RATZEBURGER ALLEE 160 D-23538 LUBECK GERMANY UNIV LUBECK,DEPT NEUROL D-23538 LUBECK GERMANY
Titolo Testata:
Neurochemistry international
fascicolo: 2, volume: 31, anno: 1997,
pagine: 307 - 311
SICI:
0197-0186(1997)31:2<307:SIDRTA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
K+ CHANNELS; SUBSTANTIA-NIGRA; BINDING-SITES; IN-VIVO; SULFONYLUREAS; ACTIVATION; DEPRENYL; MEMBRANE; NEURONS; MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C. Neusch et al., "SELEGILINE INDUCES DOPAMINE RELEASE THROUGH ATP-SENSITIVE POTASSIUM CHANNELS IN THE RAT CAUDATE-PUTAMEN IN-VITRO", Neurochemistry international, 31(2), 1997, pp. 307-311

Abstract

We used superfusion chambers to investigate the role of ATP-sensitivepotassium (K-ATP) channels in dopamine (DA) release elicited by the monoamine oxidase inhibitor seiegiline in the rat caudate-putamen in vitro. Selegiline (R[-]-deprenyl), but not the S[+] enantiomer, concentration-dependently induced increases in extracellular concentrations ofDA, with a maximal increase to 185% in comparison to basal outflow at0.1 mM selegiline. Since in our experimental conditions exclusive MAOinhibition does not lead to an enhancement of extracellular DA levels, the effect of selegiline on DA levels seems not to be related to MAOinhibition. Butanedione (0.1 mM), a specific K-ATP channel blocker, also significantly enhanced extracellular DA levels in the rat caudate-putamen to approx. 260%. Selegiline only led to an additional increaseof DA outflow, when added to submaximal concentrations of butanedioneor tolbutamide, implying that selegiline is acting on identical sites. When the K-ATP channel opener cromakalim was added to the incubationmedium, basal as well as butanedione-enhanced DA levels markedly decreased to about 40% when compared to baseline values. Selegiline-activated DA release was also antagonized by cromakalim. The selegiline effect was neither modulated by preincubation with the uptake inhibitor nomifensine nor by the DA agonist quinpirole and antagonist sulpiride. In conclusion these results suggest that selegiline is able to modulateK-ATP channels in the caudate-putamen of the rat in vitro resulting in an enhancement of striatal DA release. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:52:37