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Titolo:
Locus coeruleus involvement in the effects of immobilization stress on theP13 midlatency auditory evoked potential in the rat
Autore:
Miyazato, H; Skinner, RD; Garcia-Rill, E;
Indirizzi:
Univ Arkansas Med Sci, Dept Anat, Little Rock, AR 72205 USA Univ Arkansas Med Sci Little Rock AR USA 72205 Little Rock, AR 72205 USA Univ Ryukyus, Dept Neuropsychiat, Okinawa, Japan Univ Ryukyus Okinawa Japan Ryukyus, Dept Neuropsychiat, Okinawa, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 24, anno: 2000,
pagine: 1177 - 1201
SICI:
0278-5846(200010)24:7<1177:LCIITE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; FACTOR-LIKE IMMUNOREACTIVITY; FREELY MOVING CATS; CERULEUS NEURONS; STARTLE RESPONSE; NORADRENERGIC NEURONS; DECREASED HABITUATION; CHOLINERGIC NEURONS; CEREBRAL-CORTEX; PANIC DISORDER;
Keywords:
corticotropin releasing factor; dexmedetomidine; immobilization stress; locus coeruleus; midlatency auditory evoked potentials; pedunculopontine nucleus; posttraumatic stress disorder; yohimbine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia-Rill, E Univ Arkansas Med Sci, Dept Anat, Slot 510,4301 W Markham Ave, Little Rock, AR 72205 USA Univ Arkansas Med Sci Slot 510,4301 W MarkhamAve Little Rock AR USA 72205
Citazione:
H. Miyazato et al., "Locus coeruleus involvement in the effects of immobilization stress on theP13 midlatency auditory evoked potential in the rat", PROG NEUR-P, 24(7), 2000, pp. 1177-1201

Abstract

1. Adult male rats were prepared for recording midlatency auditory evoked responses from the vertex (Vx, P13 potential) and auditory cortex (ACx, P7 potential).2. The P13 potential is the rodent equivalent of the human P1 or P50 potential, which exhibits decreased sensory gating in posttraumatic stress disorder.3. Immobilization (IMB) stress for 60 min led to a significant decrease inP13 potential amplitude and sensory gating of the potential for the first 30-40 min of IMB.4. The effects of IMB on the P13 potential were reduced by pre-treatment with the alpha -2 adrenergic receptor blocker yohimbine (YOH).5. Injections of corticotropin releasing factor (CRF) into the locus coeruleus (LC), but not injections dorsal or Ventral to the LC, induced a dose-dependent decrease in P13 potential amplitude and sensory gating.6. The effects of CRF were blocked by cotreatment with the CRF receptor antagonist alpha -helical CRF (alpha -h CRF).7. The effects of IMB on the P13 potential were mimicked by injections of the alpha -2 adrenergic receptor agonist dexmedetomidine (DEX) into the pedunculopontine nucleus (PPN).8. The effects of DEX injections into PPN were reduced by pre-treatment with the alpha -2 adrenergic receptor blocker YOH.9. The effects of: IMB on P13 potential amplitude and sensory gating may be mediated in part via CRF activation of LC, which sends inhibitory alpha -2 adrenergic projections to PPN, a major source of the P13 potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:13:02