Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Association between TAQ1 A dopamine D-2 receptor polymorphism and psychopathology of schizophrenia in Japanese patients
Autore:
Suzuki, A; Kondo, T; Mihara, K; Furukori, H; Nagashima, U; Ono, S; Otani, K; Kaneko, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Yamagata Univ, Sch Med, Dept Neuropsychiat, Yamagata 99023, Japan YamagataUniv Yamagata Japan 99023 Neuropsychiat, Yamagata 99023, Japan
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 7, volume: 24, anno: 2000,
pagine: 1105 - 1113
SICI:
0278-5846(200010)24:7<1105:ABTADD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-VOLUNTEERS; NO ASSOCIATION; GENE; VARIANT; ALCOHOLISM; RFLP;
Keywords:
BPRS; psychopathology; schizophrenia; Taq1 A DRD2 polymorphism;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kondo, T Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 omori 0368562, Japan
Citazione:
A. Suzuki et al., "Association between TAQ1 A dopamine D-2 receptor polymorphism and psychopathology of schizophrenia in Japanese patients", PROG NEUR-P, 24(7), 2000, pp. 1105-1113

Abstract

1. Previous reports showed that the A1 allele of Taq1 A dopamine 4 receptor polymorphism was associated with lowered density and diminished function of dopamine D-2 receptor. In this study, association between Taq1 A dopamine D-2 receptor polymorphism and psychopathology of schizophrenia was investigated.2. The subjects were 61 acutely exacerbated schizophrenic patients who were all Japanese descent and had received no medication for at least one month before this study. Pretreatment psychotic symptoms were assessed by the Brief Psychiatric Rating Scale (BPRS). The Taq1 A genotypes, the A1 and A2 alleles, were determined by polymerase chain reaction method.3. The patients were divided into three genotype groups; i.e., the patients with A1/A1 allele (n=6), those with A1/A2 allele (n=32) and those with A2/A2 allele (n=23).4. There was no significant difference in total BPRS, subgrouped symptoms (positive, negative, anxiety-depression, excitement and cognitive symptoms)or any scores of BPRS items among the three Taq1 A genotype groups.5. The present study suggests that Taq1 A dopamine D-2 receptor polymorphism does not play an important role in psychopathological symptoms of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 18:05:29