Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
USEFULNESS OF PROCALCITONIN FOR DIFFERENTIATION BETWEEN ACTIVITY OF SYSTEMIC AUTOIMMUNE-DISEASE (SYSTEMIC LUPUS-ERYTHEMATOSUS SYSTEMIC ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS) AND INVASIVE BACTERIAL-INFECTION
Autore:
EBERHARD OK; HAUBITZ M; BRUNKHORST FM; KLIEM V; KOCH KM; BRUNKHORST R;
Indirizzi:
HANNOVER MED SCH,DEPT NEPHROL,KONSTANTY GUTSCHOW STR 8 D-30623 HANNOVER GERMANY STADT KLINIKUM BERLIN NEUKOLLN BERLIN GERMANY
Titolo Testata:
Arthritis and rheumatism
fascicolo: 7, volume: 40, anno: 1997,
pagine: 1250 - 1256
SICI:
0004-3591(1997)40:7<1250:UOPFDB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM PROCALCITONIN; BURNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
O.K. Eberhard et al., "USEFULNESS OF PROCALCITONIN FOR DIFFERENTIATION BETWEEN ACTIVITY OF SYSTEMIC AUTOIMMUNE-DISEASE (SYSTEMIC LUPUS-ERYTHEMATOSUS SYSTEMIC ANTINEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS) AND INVASIVE BACTERIAL-INFECTION", Arthritis and rheumatism, 40(7), 1997, pp. 1250-1256

Abstract

Objective. To investigate whether the determination of serum procalcitonin (PCT) in systemic autoimmune disease will help to discriminate invasive infection from highly active underlying disease. Methods. Three hundred ninety-seven serum samples, from 18 patients with systemic lupus erythematosus (SLE) and 35 patients with systemic antineutrophil cytoplasmic antibody-associated vasculitis (AAV), were analyzed. Clinical disease activity was assessed by the Systemic Lupus Activity Measure in SLE patients and by the Birmingham Vasculitis Activity Score in AAV patients. Procalcitonin concentrations were determined in parallelwith concentrations of neopterin, interleukin-6 (IL-6), and C-reactive protein (CRP). Additionally, serum creatinine values were obtained. Results. In 321 of the 324 samples from the 42 patients with autoimmune disease but without systemic infection, serum PCT levels were withinthe normal range (i.e., <0.5 ng/ml), whereas the values for neopterin, IL-6, and CRP were elevated in patients with active underlying disease. All 16 systemic infections occurred in 11 patients with AAV, and were associated with PCT levels that were markedly elevated, to a mean /- SD of 1.93 +/- 1.19 ng/ml. No correlation between the degree of renal impairment and PCT concentrations was seen. Conclusion. PCT may serve as a useful marker for the detection of systemic bacterial infection in patients with systemic autoimmune disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 05:55:36