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Titolo:
ACTIVATION OF HEAT-SHOCK TRANSCRIPTION FACTOR-3 BY C-MYB IN THE ABSENCE OF CELLULAR STRESS
Autore:
KANEIISHII C; TANIKAWA J; NAKAI A; MORIMOTO RI; ISHII S;
Indirizzi:
RIKEN,TSUKUBA LIFE SCI CTR,MOL GENET LAB TSUKUBA IBARAKI 305 JAPAN RIKEN,TSUKUBA LIFE SCI CTR,MOL GENET LAB TSUKUBA IBARAKI 305 JAPAN KYOTO UNIV,DEPT CELL BIOL,CHEST DIS RES INST KYOTO 606 JAPAN NORTHWESTERN UNIV,DEPT BIOCHEM MOL BIOL & CELL BIOL,RICE INST BIOMED RES EVANSTON IL 60208 OSAKA UNIV,MICROBIAL DIS RES INST SUITA OSAKA 565 JAPAN
Titolo Testata:
Science
fascicolo: 5323, volume: 277, anno: 1997,
pagine: 246 - 248
SICI:
0036-8075(1997)277:5323<246:AOHTFB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HSP70 GENE-TRANSCRIPTION; DNA-BINDING ABILITY; COILED-COIL; MOLECULAR-CLONING; LEUCINE-ZIPPER; OLIGOMERIZATION; EXPRESSION; HSF1; TRANSACTIVATION; TRIMERIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C. Kaneiishii et al., "ACTIVATION OF HEAT-SHOCK TRANSCRIPTION FACTOR-3 BY C-MYB IN THE ABSENCE OF CELLULAR STRESS", Science, 277(5323), 1997, pp. 246-248

Abstract

In vertebrates, the presence of multiple heat shock transcription factors (HSFs) indicates that these factors may be regulated by distinct stress signals. HSF3 was specifically activated in unstressed proliferating cells by direct binding to the c-myb proto-oncogene product (c-Myb). These factors formed a complex through their DNA binding domains that stimulated the nuclear entry and formation of the transcriptionally active trimer of HSF3. Because c-Myb participates in cellular proliferation, this regulatory pathway may provide a link between cellular proliferation and the stress response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:04:40