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Titolo:
The "two-headed" peptide inhibitors of interleukin-1 action
Autore:
Kluczyk, A; Siemion, IZ; Wieczorek, Z;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland Polish Acad Sci Wroclaw Poland PL-53114 herapy, PL-53114 Wroclaw, Poland
Titolo Testata:
PEPTIDES
fascicolo: 9, volume: 21, anno: 2000,
pagine: 1411 - 1420
SICI:
0196-9781(200009)21:9<1411:T"PIOI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; CRYSTAL-STRUCTURE; RESOLUTION; FRAGMENTS; PROTEINS; DESIGN; FAMILY;
Keywords:
interleukin-1; interleukin-1 receptor antagonist; IL-1 inhibitors; thymopentin; peptide immunosuppressors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Siemion, IZ Univ Wroclaw, Fac Chem, Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw Joliot Curie 14 Wroclaw Poland PL-50383 , Poland
Citazione:
A. Kluczyk et al., "The "two-headed" peptide inhibitors of interleukin-1 action", PEPTIDES, 21(9), 2000, pp. 1411-1420

Abstract

Two peptide fragments of IL-I family proteins, ITGSE and VTKFYF compete with IL-I for the cellular receptor. We synthesized a series of peptides composed of the sequences ITGSE and VTKFYK bound directly to each other or connected by such linkers as (Gly)(n), L- and D-Pro residues, Glu and Lys residues (with peptide bond formed by main amino and carboxy groups or by side chain groups), and p-alanine and its homologues. Peptide IX with a gamma -Glu linker was the most potent inhibitor of IL-1 action. It was twice as potent as both of the peptides indicated. (C) 2000 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:00:23