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Titolo:
Age-related changes in the neuropeptide Y effects on murine lymphoproliferation and interleukin-2 production
Autore:
Medina, S; Del Rio, M; Hernanz, A; De la Fuente, M;
Indirizzi:
Univ Complutense, Dept Biol Anim Fisiol Anim 2, Fac Ciencias Biol, E-28040Madrid, Spain Univ Complutense Madrid Spain E-28040 iencias Biol, E-28040Madrid, Spain Hosp La Paz del Insalud, Serv Bioquim, Madrid, Spain Hosp La Paz del Insalud Madrid Spain salud, Serv Bioquim, Madrid, Spain
Titolo Testata:
PEPTIDES
fascicolo: 9, volume: 21, anno: 2000,
pagine: 1403 - 1409
SICI:
0196-9781(200009)21:9<1403:ACITNY>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; SULFATED CHOLECYSTOKININ-OCTAPEPTIDE; PROTEIN-KINASE-C; T-CELL; CYTOKINE PRODUCTION; SUBSTANCE-P; PROLIFERATION; MODULATION; LYMPHOCYTES; IMMUNOSENESCENCE;
Keywords:
aging; neuropeptide Y; lymphoproliferation; IL-2; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Dept Biol Anim Fisiol Anim 2, Fac Ciencias Biol, E-28040Madrid, Spain Univ Complutense Madrid Spain E-28040 28040Madrid, Spain
Citazione:
S. Medina et al., "Age-related changes in the neuropeptide Y effects on murine lymphoproliferation and interleukin-2 production", PEPTIDES, 21(9), 2000, pp. 1403-1409

Abstract

Neuropeptide Y (NPY) modulates several aspects of the immune response but it is not known whether NPY responsiveness is altered with aging. In this work, the in vitro effect of NPY at concentrations ranging from 10(-14) M to10(-7) M on lymphoproliferation has been studied in spleen, axillary node and thymus leukocytes from young, adult, mature and old BALB/c mice. The spontaneous proliferation of spleen lymphocytes from young mice was significantly stimulated by NPY. In response to the mitogen Con A, lymphoproliferation and IL-2 release by lymphocytes were inhibited significantly by NPY, these effects disappearing with aging. The results show that NPY is a modulator of lymphoproliferation and that this effect disappears progressively withage. Moreover, this regulatory role of NPY may be carried out through a decrease in IL-2 production. (C) 2000 Published by Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 23:18:25