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Titolo:
Transthyretin and transferrin in hemangioblastoma stromal cells
Autore:
Bleistein, M; Geiger, K; Franz, K; Stoldt, P; Schlote, W;
Indirizzi:
Univ Marburg, Abt Neuropathol, Dept Neuropathol, D-35043 Marburg, Germany Univ Marburg Marburg Germany D-35043 uropathol, D-35043 Marburg, Germany Univ Frankfurt, Dept Neuropathol, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 athol, D-6000 Frankfurt, Germany Univ Frankfurt, Dept Neurosurg, D-6000 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-6000 osurg, D-6000 Frankfurt, Germany
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 10, volume: 196, anno: 2000,
pagine: 675 - 681
SICI:
0344-0338(2000)196:10<675:TATIHS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; CHOROID-PLEXUS EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; NERVOUS-SYSTEM; CEREBELLAR HEMANGIOBLASTOMAS; CAPILLARY HEMANGIOBLASTOMA; HUMAN-BRAIN; LINDAU DISEASE; LOCALIZATION; HISTOGENESIS;
Keywords:
hemangioblastoma; stromal cells; transthyretin; transferrin; collagen IV; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Bleistein, M Univ Marburg, Abt Neuropathol, Dept Neuropathol, Baldingerstr, D-35043 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35043 g, Germany
Citazione:
M. Bleistein et al., "Transthyretin and transferrin in hemangioblastoma stromal cells", PATH RES PR, 196(10), 2000, pp. 675-681

Abstract

Hemangioblastoma, a rare benign tumor of the CNS, consists of two main components: capillaries and stromal cells. Despite many efforts, the histogenesis of stromal cells is still unknown. We took a new approach to clarify the origin of stromal cells using immunohistochemical methods. Paraffin-embedded tissue of 24 surgically removed hemangioblastomas of the CNS was examined with antibodies against transthyretin, transferrin, vimentin, NSE, protein S-100, CK 8, KL-1, EMA, CD34, factor VIII rAg, and collagen IV. Stromal cells showed a positive reaction with anti-transthyretin in 12 of 24 hemangioblastomas, a positive reaction with anti-transferrrin, to a different extent, in 13 of 24 cases, and many stromal cells expressed basal membrane collagen IV on the cell surface in 19 of 24 cases. The expression of transthyretin and transferrin in stromal cells of hemangioblastomas is reported for the first time, thus providing an antigenic profile of hemangioblastoma stromal cells that is very similar to that of immature choroid plexus epithelium. These findings support the notion that hemangioblastoma stromal cells may originate from the embryonal plexus epithelium. We discuss our results with special regard to stromal cell histogenesis, including a review of the literature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:31:50