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Titolo:
Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis
Autore:
Imatani, T; Kato, T; Minaguchi, K; Okuda, K;
Indirizzi:
Tokyo Dent Coll, Dept Microbiol, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll Chiba Japan 2618502 iol, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll, Oral Hlth Sci Ctr, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll Chiba Japan 2618502 Ctr, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll, Dept Forens Odontol, Mihama Ku, Chiba 2618502, Japan Tokyo Dent Coll Chiba Japan 2618502 tol, Mihama Ku, Chiba 2618502, Japan
Titolo Testata:
ORAL MICROBIOLOGY AND IMMUNOLOGY
fascicolo: 6, volume: 15, anno: 2000,
pagine: 378 - 382
SICI:
0902-0055(200012)15:6<378:H5IICI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SALIVARY HISTATINS; BUCCAL EPITHELIAL-CELLS; HISTIDINE-RICH PROTEINS; BACTEROIDES-GINGIVALIS; NEISSERIA-GONORRHOEAE; GROWTH-FACTOR; INTERLEUKIN-6; ASACCHAROLYTICUS; PURIFICATION; INFECTION;
Keywords:
histatin 5; Porphyromonas gingivalis; inflammatory cytokine; inhibition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Imatani, T Tokyo Dent Coll, Dept Microbiol, Mihama Ku, 1-2-2 Masago, Chiba2618502, Japan Tokyo Dent Coll 1-2-2 Masago Chiba Japan 2618502 618502, Japan
Citazione:
T. Imatani et al., "Histatin 5 inhibits inflammatory cytokine induction from human gingival fibroblasts by Porphyromonas gingivalis", ORAL MICROB, 15(6), 2000, pp. 378-382

Abstract

Porphyromonas gingivalis is a gram-negative rod associated with the progression of human periodontal disease. It has been demonstrated that outer-membrane proteins as well as lipopolysaccharides from P. gingivalis ATCC 53977can induce interleukin 6 (IL-6) and IL-8 from the cells of the periodontium in vitro. But, they cannot induce IL-l and tumor necrosis factor-ct from the cells. In the present study. we studied the effects of salivary proteinon cytokine induction from human gingival fibroblasts by P. gingivalis outer-membrane protein. Histatin 5 suppressed the IL-6 and IL-8 induction by P. gingivalis outer-membrane protein. This activity was more effective when outer-membrane protein was incubated with histatin 5 before addition to thecell culture. The present study indicates that histatin 5 restrains induction of inflammatory cytokines by periodontal pathogens and that histatin isone of the salivary proteins responsible for this activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:11:06