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Titolo:
The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain
Autore:
Meikle, SR; Eberl, S; Fulton, RR; Kassiou, M; Fulham, MJ;
Indirizzi:
Royal Prince Alfred Hosp, Dept PET & Nucl Med, Sydney, NSW, Australia Royal Prince Alfred Hosp Sydney NSW Australia ed, Sydney, NSW, Australia
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 27, anno: 2000,
pagine: 617 - 625
SICI:
0969-8051(200008)27:6<617:TIOTSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RESOLUTION PET; NOISE PROPERTIES; EM ALGORITHM; SCANNER; MODEL; PERFORMANCE; MICROPET; RECEPTOR; ANIMALS;
Keywords:
small animal imaging; PET; rat brain; tracer kinetics; parameter estimation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Meikle, SR Royal Prince Alfred Hosp, Dept PET & Nucl Med, Missenden Rd, Camperdown, NSW 2050, Australia Royal Prince Alfred Hosp Missenden Rd Camperdown NSW Australia 2050
Citazione:
S.R. Meikle et al., "The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain", NUCL MED BI, 27(6), 2000, pp. 617-625

Abstract

We investigated the influence of tomograph sensitivity on reliability of parameter estimation in positron emission tomography studies of the rat brain. The kinetics of two tracers in rat striatum and cerebellum were simulated. A typical injected dose of 10 MBq and a reduced dose of 1 MBq were assumed. Kinetic parameters were estimated using a region of interest (ROI) analysis and two pixel-by pixel analyses. Striatal binding potential was estimated as a function of effective tomograph sensitivity (S-eff) using a simplified reference tissue model. A S-eff value of greater than or equal to 1% was required to ensure reliable parameter estimation for ROT analysis and a S-eff of 3-6% was required for pixel-by pixel analysis. We conclude that effective tomograph sensitivity of 3% may be an appropriate design goal for rat brain imaging. NUCL MED BIOL 27;6: 617-625, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 22:30:24