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Titolo:
Characterization of In-111(3+) complexes of DTPA amide derivatives: Biodistribution and clearance studied by gamma imaging
Autore:
Prata, MIM; Santos, AC; Bligh, SWA; Chowdhury, AHMS; Geraldes, CFGC; de Lima, JJP;
Indirizzi:
Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 t Bioquim, P-3000 Coimbra, Portugal Univ Coimbra, Fac Med, Serv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra Coimbra Portugal rv Biofis & Biomatemat, Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, P-3000 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3000 ociencias, P-3000 Coimbra, Portugal Univ N London, Sch Biol & Appl Sci, London N7 8DB, England Univ N London London England N7 8DB l & Appl Sci, London N7 8DB, England
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 6, volume: 27, anno: 2000,
pagine: 605 - 610
SICI:
0969-8051(200008)27:6<605:COICOD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL CONTRAST AGENTS; MAGNETIC-RESONANCE; AQUEOUS-SOLUTION; METAL-IONS; RADIOPHARMACEUTICALS;
Keywords:
albumin; gamma imaging; In-111(3+) complexes; DTPA derivatives;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Geraldes, CFGC Univ Coimbra, Fac Ciencias & Tecnol, Dept Bioquim, Apartado3126, P-3000 Coimbra, Portugal Univ Coimbra Apartado 3126 Coimbra Portugal P-3000 ortugal
Citazione:
M.I.M. Prata et al., "Characterization of In-111(3+) complexes of DTPA amide derivatives: Biodistribution and clearance studied by gamma imaging", NUCL MED BI, 27(6), 2000, pp. 605-610

Abstract

A large series of structurally related diethylenetriaminepentaacetic acid amide derivatives with different structures and lipophilic properties were synthesized and radiolabeled with In-111(3+). TWO Of the more hydrophobic compounds studied ([In-111]L-9 and [In-111]L-10) showed high affinity for human serum albumin (HSA). The biodistribution and clearance properties shownby all complexes upon injection in Wistar rats were followed by gamma imaging. The blood retention time of the chelates correlates better with their binding to HSA than with their hydrophilic/lipophilic ratio. Hydrophile andnegatively charged complexes undergo renal retention, while the majority of the lipophilic complexes are retained in the blood for a longer period oftime and are cleared through the liver. NUCL MED BIOL 21;6:605-610, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:03:11