Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Relapses and progression of disability in multiple sclerosis.
Autore:
Confavreux, C; Vukusic, S; Moreau, T; Adeleine, P;
Indirizzi:
Hop Neurol, EDMUS Coordinating Ctr, F-69394 Lyon 03, France Hop Neurol Lyon France 03 DMUS Coordinating Ctr, F-69394 Lyon 03, France Hop Neurol, Serv Neurol A, F-69394 Lyon, France Hop Neurol Lyon France F-69394 urol, Serv Neurol A, F-69394 Lyon, France Hospices Civils Lyon, Unite Biostat & Informat Med, Lyon, France Hospices Civils Lyon Lyon France e Biostat & Informat Med, Lyon, France
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 20, volume: 343, anno: 2000,
pagine: 1430 - 1438
SICI:
0028-4793(20001116)343:20<1430:RAPODI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-HISTORY; CLINICAL COURSE; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Confavreux, C Hop Neurol, EDMUS Coordinating Ctr, 59 Pinel Bvd, F-69394 Lyon 03, France Hop Neurol 59 Pinel Bvd Lyon France 03 9394 Lyon 03, France
Citazione:
C. Confavreux et al., "Relapses and progression of disability in multiple sclerosis.", N ENG J MED, 343(20), 2000, pp. 1430-1438

Abstract

Background: The influence of the patterns of onset of multiple sclerosis and relapses of the disease on the time course of irreversible disability iscontroversial. Methods: In 1844 patients who had had multiple sclerosis for a mean (+/-SD) of 11+/-10 years, we determined the time of the clinical onset of the disease, the initial course (relapsing-remitting or progressive) and the subsequent course (relapsing-remitting, secondary progressive, or primary progressive), the times of relapses, the time to the onset of irreversible disability, and the time course of progressive, irreversible disability. We used three scores on the Kurtzke Disability Status Scale (range, 0 to 10, with higher scores indicating more severe disability) as measures of the severityand progression of disability: a score of 4 (limited walking ability but able to walk more than 500 m without aid or rest), a score of 6 (ability to walk with unilateral support no more than 100 m without rest), and a score of 7 (ability to walk no more than 10 m without rest while leaning against a wall or holding onto furniture for support). We used Kaplan-Meier analyses to determine the influence of relapses on the time to the onset of irreversible disability. Results: The median times from the onset of multiple sclerosis to the assignment of a score of 4, a score of 6, and a score of 7 on the disability scale were longer among the 1562 patients with a relapsing-remitting onset ofdisease (11.4, 23.1, and 33.1 years, respectively) than among the 282 patients who had progressive disease from the onset (0.0, 7.1, and 13.4 years, respectively; P<0.001 for all comparisons). In contrast, the times from theassignment of a score of 4 to a score of 6 were similar in the two groups (5.7 and 5.4 years, P=0.74). The time course of progressive, irreversible disease among patients with the primary progressive type of multiple sclerosis was not affected by the presence or absence of superimposed relapses. Conclusions: Among patients with multiple sclerosis, relapses do not significantly influence the progression of irreversible disability. (N Engl J Med 2000; 343:1430-8. ) (C) 2000, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:48:36