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Titolo:
Neuron-independent Ca2+ signaling in glial cells of snail's brain
Autore:
Kojima, S; Ogawa, H; Kouuchi, T; Nidaira, T; Hosono, T; Ito, E;
Indirizzi:
Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Lab Anim Behav & Intelligence,Kita Ku, Sapporo, Hokkaido 0600810, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600810 oro, Hokkaido 0600810, Japan Saitama Med Sch, Dept Biol, Moroyama, Saitama 3500496, Japan Saitama Med Sch Moroyama Saitama Japan 3500496 ma, Saitama 3500496, Japan Hamamatsu Photon KK, Syst Div, Hamamatsu, Shizuoka 4313196, Japan Hamamatsu Photon KK Hamamatsu Shizuoka Japan 4313196 zuoka 4313196, Japan
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 100, anno: 2000,
pagine: 893 - 900
SICI:
0306-4522(2000)100:4<893:NCSIGC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED TASTE-AVERSION; SYSTEM MYELINATED AXONS; VOLTAGE-SENSITIVE DYES; LYMNAEA-STAGNALIS; POND SNAIL; NERVOUS-SYSTEM; FEEDING RESPONSE; TENTACLE NERVES; CALCIUM; APLYSIA;
Keywords:
glial cell; slow depolarizing response; L-type Ca2+ channel; optical recording; voltage-sensitive dye; gastropod mollusc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, E Hokkaido Univ, Grad Sch Sci, Div Biol Sci, Lab Anim Behav & Intelligence,Kita Ku, North 10,West 8, Sapporo, Hokkaido 0600810, Japan Hokkaido Univ North 10,West 8 Sapporo Hokkaido Japan 0600810 Japan
Citazione:
S. Kojima et al., "Neuron-independent Ca2+ signaling in glial cells of snail's brain", NEUROSCIENC, 100(4), 2000, pp. 893-900

Abstract

To directly monitor the glial activity in the CNS of the pond snail, Lymnaea stagnalis, we optically measured the electrical responses in the cerebral ganglion and median lip nerve to electrical stimulation of the distal endof the median lip nerve. Using a voltage-sensitive dye, RH155, we detecteda composite depolarizing response in the cerebral ganglion, which consisted of a fast transient depolarizing response corresponding to a compound action potential and a slow depolarizing response. The slow depolarizing response was observed more clearly in an isolated median lip nerve and also detected by extracellular recording. In the median lip nerve preparation, the slow depolarizing response was suppressed by an L-type Ca2+ channel blocker,nifedipine, and was resistant to tetrodotoxin and Na+-free conditions. Together with the fact that a delay from the compound action potential to the slow depolarizing response was not constant, these results suggested that the slow depolarizing response was not a postsynaptic response. Because the signals of the action potentials appeared on the saturated slow depolarizing responses during repetitive stimulation, the slow depolarizing response was suggested to originate from glial cells. The contribution of the L-type Ca2+ current to the slow depolarizing response was confirmed by optical recording in the presence of Ba2+ and also supported by intracellular Ca2+ measurement. Our results suggested that electrical stimulation directly triggers glial Ca2+ entry through L-type Ca2+ channels, providing evidence for the generation of glial depolarization independent of neuronal activity in invertebrates. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:00:13