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Titolo:
Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome
Autore:
Heidbreder, CA; Weiss, IC; Domeney, AM; Pryce, C; Homberg, J; Hedou, G; Feldon, J; Moran, MC; Nelson, P;
Indirizzi:
SmithKline Beecham Pharmaceut, Dept Neurosci, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AW ssex, England Swiss Fed Inst Technol, Lab Behav Biol, Zurich, Switzerland Swiss Fed InstTechnol Zurich Switzerland hav Biol, Zurich, Switzerland SmithKline Beecham Pharmaceut, Dept Stat Sci, Harlow CM19 5AD, Essex, England SmithKline Beecham Pharmaceut Harlow Essex England CM19 5AD ssex, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 100, anno: 2000,
pagine: 749 - 768
SICI:
0306-4522(2000)100:4<749:BNAECO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; SPATIAL DELAYED ALTERNATION; CENTRAL AMYGDALOID NUCLEUS; ACOUSTIC STARTLE RESPONSE; MEDIAL PREFRONTAL CORTEX; PREPULSE INHIBITION; LOCOMOTOR-ACTIVITY; CONDITIONED STRESS; HOARDING BEHAVIOR; DOPAMINERGIC TRANSMISSION;
Keywords:
caging conditions; dopamine; interhemispheric coupling; principal components analysis; serotonin; social isolation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
91
Recensione:
Indirizzi per estratti:
Indirizzo: Heidbreder, CA SmithKline Beecham Pharmaceut, Dept Neurosci, New FrontiersSci Pk N,Bldg H25,Room 104A, Harlow CM19 5AW, Essex, England SmithKline Beecham Pharmaceut New Frontiers Sci Pk N,Bldg H25,Room 104A Harlow Essex England CM19 5AW
Citazione:
C.A. Heidbreder et al., "Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome", NEUROSCIENC, 100(4), 2000, pp. 749-768

Abstract

Rearing rats in isolation has been shown to be a relevant paradigm for studying early life stress and understanding the genesis of depression and related affective disorders. Recent studies from our laboratory point to the relevance of studying the social isolation syndrome as a function of home caging conditions. Accordingly, the present series of experiments assessed the contribution of each condition to the expression of the prepulse inhibition of the acoustic startle, food hoarding and spontaneous locomotor activity. In addition, ex vivo neurochemical changes in the brains of isolated andgrouped rats reared either in sawdust-lined or in grid-floor cages were determined by measuring dopamine and serotonin as well as their major metabolites in a "psychosis circuit" that includes mainly the hippocampus and selected hippocampal efferent pathways projecting towards the anterior cingulate and infralimbic cortices, nucleus accumbens, dorsolateral caudate nucleus, amygdala and entorhinal cortex. The results of the present study demonstrate that rearing rats in isolation (i) produces a syndrome of generalized locomotor hyperactivity; (ii) increases the startle response; (iii) impairs prepulse inhibition; (iv) tends to increase food hoarding behavior; (v) increases basal dopamine turnover in the amygdaloid complex: (vi) decreases basal dopamine turnover in the infralimbic part of the medial prefrontal cortex; and (vii) decreases basal turnover of serotonin in the nucleus accumbens. In the entorhinal cortex, dopamine neurotransmission seemed to be more sensitive to the caging conditions since a decreased basal turnover of dopamine was observed in grid-reared animals. Plasma corticosterone levels were also increased in grid-reared animals compared with rats reared in sawdust cages. Finally, isolates reared on grids showed a significant positive correlation between plasma corticosterone levels and dopamine in the left nucleus accumbens. Altogether, these results support the contention that there is a link between social isolation, attention deficit, spontaneous locomotor hyperactivity and reduced dopamine turnover in the medial prefrontal cortex. Furthermore, our data demonstrate that rearing rats in grid-floor cages represents a form of chronic mild stress associated with increased corticosterone levels, decreased basal turnover of entorhinal dopamine and increased dopamine activity in the left nucleus accumbens. Finally, a significant and selective decrease in the basal turnover of serotonin in the nucleus accumbens of isolated rats may be linked to the isolation-induced locomotor hyperactivity. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:04:25