Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Quantal release of serotonin
Autore:
Bruns, D; Riedel, D; Klingauf, J; Jahn, R;
Indirizzi:
Max Planck Inst Biophys Chem, Dept Neurobiol, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37077 ottingen, Germany Max Planck Inst Biophys Chem, Dept Membrane Biophys, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-37077 ottingen, Germany
Titolo Testata:
NEURON
fascicolo: 1, volume: 28, anno: 2000,
pagine: 205 - 220
SICI:
0896-6273(200010)28:1<205:QROS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFIED LEECH NEURONS; VESICULAR MONOAMINE TRANSPORTER-2; CULTURED HIPPOCAMPAL-NEURONS; ADRENAL CHROMAFFIN CELLS; DENSE CORE VESICLES; SYNAPTIC VESICLES; TRANSMITTER CONCENTRATION; NEUROENDOCRINE CELLS; SECRETORY GRANULES; SUBSTANTIA-NIGRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Bruns, D Max Planck Inst Biophys Chem, Dept Neurobiol, Fassberg 11, D-37077 Gottingen, Germany Max Planck Inst Biophys Chem Fassberg 11 Gottingen Germany D-37077
Citazione:
D. Bruns et al., "Quantal release of serotonin", NEURON, 28(1), 2000, pp. 205-220

Abstract

We have studied the origin of quantal Variability for small synaptic Vesicles (SSVs) and large dense-cored vesicles (LDCVs). As a model, we used serotonergic Retzius neurons of leech that allow for combined amperometrical and morphological analyses of quantal transmitter release. We find that the transmitter amount released by a SSV varies proportionally to the volume of the vesicle, suggesting that serotonin is stored at a constant intravesicular concentration and is completely discharged during exocytosis. Transmitter discharge from LDCVs shows a higher degree of variability than is expected from their size distribution, and bulk release from LDCVs is slower than release from SSVs. On average, differences in the transmitter amount released from SSVs and LDCVs are proportional to the size differences of the organelles, suggesting that transmitter is stored at similar concentrations in SSVs and LDCVs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:36:24