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Titolo:
[I-123]beta-CIT SPECT in multiple system atrophy, progressive supranuclearpalsy, and corticobasal degeneration
Autore:
Pirker, W; Asenbaum, S; Bencsits, G; Prayer, D; Gerschlager, W; Deecke, L; Brucke, T;
Indirizzi:
Univ Vienna, Dept Clin Neurol, A-1090 Vienna, Austria Univ Vienna ViennaAustria A-1090 pt Clin Neurol, A-1090 Vienna, Austria Univ Vienna, Dept Nucl Med, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Dept Nucl Med, A-1090 Vienna, Austria Univ Vienna, Dept Radiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 a, Dept Radiol, A-1090 Vienna, Austria Wilhelminenspital Stadt Wien, Dept Neurol, Vienna, Austria Wilhelminenspital Stadt Wien Vienna Austria ept Neurol, Vienna, Austria
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 6, volume: 15, anno: 2000,
pagine: 1158 - 1167
SICI:
0885-3185(200011)15:6<1158:[SIMSA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PARKINSONS-DISEASE; I-123 BETA-CIT; RICHARDSON-OLSZEWSKI-SYNDROME; PHOTON EMISSION TOMOGRAPHY; DOPAMINE TRANSPORTERS; HUMAN-BRAIN; CLINICAL-DIAGNOSIS; STRIATONIGRAL DEGENERATION; SEROTONIN TRANSPORTERS; UPTAKE SITES;
Keywords:
[I-123]beta-CIT; corticobasal degeneration; dopamine transporter; multiple system atrophy; progressive supranuclear palsy; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Pirker, W Univ Vienna, Dept Clin Neurol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 ustria
Citazione:
W. Pirker et al., "[I-123]beta-CIT SPECT in multiple system atrophy, progressive supranuclearpalsy, and corticobasal degeneration", MOVEMENT D, 15(6), 2000, pp. 1158-1167

Abstract

Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical,grounds. We studied the pattern of dopaminergic degeneration in 18 patients with probable MSA, 8 patients with PSP, 4 patients with CBD, 48 patients with PD and a similar degree of disability, and 14 control subjects per forming single photon emission computed tomography (SPECT) 20 hours after injection of [I-123]beta -CIT. Overall striatal binding was significantly reduced in MSA (-51% of normal mean), PSP (-60%), CBD (-35%), and PD (-58%), without overlap with control values. Asymmetry ofstriatal beta -CIT binding was significantly increased in patients with CBD and PD, as compared with control subjects. Although asymmetry seemed to be less pronounced in MSA and PSP than in PD, this was not statistically significant. Putamen-caudate nucleus ratios in patients with PD, MSA, and PSP,but not with CBD, were significantly reduced, as compared with control subjects. In conclusion, [I-123]beta -CIT SPECT reliably enables the visualization of the presynaptic dopaminegic lesion in patients with MSA, PSP, and CBD. In most patients, however, it does nor seem to be possible to differentiate these disorders from PD with this method.

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Documento generato il 17/09/19 alle ore 22:48:25