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Titolo:
Plasticity of the superior olivary complex
Autore:
Illing, RB; Kraus, KS; Michler, SA;
Indirizzi:
Univ Freiburg, HNO Klin, Neurobiol Res Lab, Dept Otorhinolaryngol, D-79106Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 aryngol, D-79106Freiburg, Germany
Titolo Testata:
MICROSCOPY RESEARCH AND TECHNIQUE
fascicolo: 4, volume: 51, anno: 2000,
pagine: 364 - 381
SICI:
1059-910X(20001115)51:4<364:POTSOC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY BRAIN-STEM; ADULT-RAT BRAIN; SINGLE OLIVOCOCHLEAR NEURONS; FOS-LIKE IMMUNOREACTIVITY; MESSENGER-RNA EXPRESSION; INDUCED HEARING-LOSS; OUTER HAIR-CELLS; TEMPORARY THRESHOLD SHIFTS; COCHLEAR EFFERENT SYSTEM; LONG-TERM POTENTIATION;
Keywords:
auditory system; cochlear nucleus; inferior colliculus; cochleotomy; ossicular removal;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
189
Recensione:
Indirizzi per estratti:
Indirizzo: Illing, RB Univ Freiburg, HNO Klin, Neurobiol Res Lab, Dept Otorhinolaryngol, Killianst 5, D-79106 Freiburg, Germany Univ Freiburg Killianst 5 Freiburg Germany D-79106 rg, Germany
Citazione:
R.B. Illing et al., "Plasticity of the superior olivary complex", MICROSC RES, 51(4), 2000, pp. 364-381

Abstract

The superior olivary complex (SOC) is part of the auditory brainstem of the vertebrate brain. Residing ventrally in the rhombencephalon, it receives sensory signals from both cochleae through multisynaptic pathways. Neurons of the SOC are also a target of bilateral descending projections. Ascendingand descending efferents of the SOC affect the processing of auditory signals on both sides of the brainstem and in both organs of Corti. The patternof connectivity indicates that the SOC fulfills functions of binaural signal integration serving sound localization. But whereas many of these connectional features are shared with the inferior colliculus (with the importantexception of a projection to the inner ear), cellular and molecular investigations have shown that cells residing in SOC are unique in several respects. Unlike those of other auditory brainstem nuclei, they specifically express molecules known to be involved in development, plasticity, and learning(e.g.,GAP-43 mRNA, specific subunits of integrin). Moreover, neurons of the SOC in adult mammals respond to various kinds of hearing impairment with the expression of plasticity-related substances (e.g., GAP-43, c-Jun, c-Fos, cytoskeletal elements), indicative of a restructuring of auditory connectivity. These observations suggest that the SOC is pivotal in the developmental and adaptive tuning of binaural processing in young and adult vertebrates. Microsc. Res. Tech. 51:364-381, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:27:15