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Titolo:
Evaluation of red blood cell aggregation in diabetes by computarized imageanalysis
Autore:
Foresto, P; DArrigo, M; Carreras, L; Cuezzo, RE; Valverde, J; Rasia, R;
Indirizzi:
Univ Nacl Rosario, Lab Inmunohemorreol, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe, Argentina Univ Nacl Rosario Rosario Santa Fe Argentina RA-2000 Santa Fe, Argentina Univ Nacl Rosario, IFIR, Fac Ciencias Bioquim & Farmaceut, CONICET, RA-2000 Rosario, Santa Fe, Argentina Univ Nacl Rosario Rosario Santa Fe Argentina RA-2000 Santa Fe, Argentina
Titolo Testata:
MEDICINA-BUENOS AIRES
fascicolo: 5, volume: 60, anno: 2000,
pagine: 570 - 572
SICI:
0025-7680(2000)60:5<570:EORBCA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIALIC-ACID; MELLITUS; VISCOSITY;
Keywords:
red blood cell aggregation; diabetes; vascular diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Foresto, P Dorrego 2366, RA-2000 Rosario, Santa Fe, Argentina Dorrego 2366 Rosario Santa Fe Argentina RA-2000 Fe, Argentina
Citazione:
P. Foresto et al., "Evaluation of red blood cell aggregation in diabetes by computarized imageanalysis", MEDICINA, 60(5), 2000, pp. 570-572

Abstract

Red blood cell (RBC) aggregation has been widely studied and its importance is well established in the rheology of microcirculation. RBC aggregation is a major factor responsible for the flow properties of blood. Increased RBC aggregation has been observed in several pathological states. Therefore,the measurement of erythrocyte aggregation is theologically important for quantifying flow abnormality in pathological conditions. Normal RBC under low flow or at rest form rouleaux aggregates, while abnormal RBC aggregationmay lead to the formation of irregular aggregate structures, which may be induced by cell-associated factors (reduced membrane sialic acid levels) but also by extracellular factors. The main objective of the present investigation was to study RBC aggregate morphology in diabetic patients, using direct microscopic observation and numerical processing of recorded digitized images. Blood samples were obtained from 20 diabetic patients and from 15 normal control subjects. The aggregate morphology was quantified by the so-called Aggregate Shape Parameter (ASP) defined as the ratio of the aggregateprojected area to its square perimeter. ASP appeared significantly higher (p < 10(5)) in diabetic patients (0.65 +/- 0.18) than in normal controls (0.28 +/- 0.15). This rheo-optical method based on the theoretical model for rouleaux aggregates provides a useful reference for measuring deviations ofRBC aggregate morphology. Increased aggregation of RBC resulting from a decreased sialylation of glycophorins may be an important factor in the development of vascular diseases and in the microcirculation impairment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 05:00:58