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Titolo:
Transit time, trailing time, and cerebral blood flow during brain activation: Measurement using multislice, pulsed spin-labeling perfusion imaging
Autore:
Yang, YH; Engelien, W; Xu, S; Gu, H; Silbersweig, DA; Stern, E;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, New York, NY 10021 USA Cornell Univ New York NY USA 10021 uroimaging Lab, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 5, volume: 44, anno: 2000,
pagine: 680 - 685
SICI:
0740-3194(200011)44:5<680:TTTTAC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR ACTIVATION; ARTERIAL WATER; STEADY-STATE; INVERSION; INCREASES; QUANTIFICATION; SPECTROSCOPY; QUANTITATION; FREQUENCY;
Keywords:
transit time; trailing time; CBF; perfusion MRI; brain activation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, YH Cornell Univ, Weill Med Coll, Dept Psychiat, Funct Neuroimaging Lab, 525 E68th St,Box 140,Room F-1306, New York, NY 10021 USA Cornell Univ 525 E 68th St,Box 140,Room F-1306 New York NY USA 10021
Citazione:
Y.H. Yang et al., "Transit time, trailing time, and cerebral blood flow during brain activation: Measurement using multislice, pulsed spin-labeling perfusion imaging", MAGN RES M, 44(5), 2000, pp. 680-685

Abstract

Transit time and trailing time in pulsed spin-labeling perfusion imaging are likely to be modulated by local blood flow changes, such as those accompanying brain activation. The majority of transit/trailing time is due to the passage of the tagged blood bolus through the arteriole/capillary regions, because of lower blood flow velocity in these regions. Changes of transit/trailing time during activation could affect the quantification of CBF in functional neuroimaging studies, and are therefore important to characterize. In this work, the measurement of transit and trailing times and CBF during sensorimotor activation using multislice perfusion imaging with pulsed arterial spin-labeling is described. While CBF elevated dramatically (similar to 80.7%) during the sensorimotor activation, sizable reductions of transit time (similar to0.11 sec) and trailing time (similar to0.26 sec) were observed. Transit and trailing times were dependent on the distances from theleading and trailing edges of the tagged blood bolus to the location of the imaging slices, The effects of transit/trailing time changes on CBF quantification during brain activation were analyzed by simulation studies, significant errors can be caused in the estimation of CBF if such changes of transit/trailing time are not taken into account. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:05:41