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Titolo:
Chemoembolization of liver tumor in a rabbit model: Assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis
Autore:
Geschwind, JFH; Artemov, D; Abraham, S; Omdal, D; Huncharek, MS; McGee, C; Arepally, A; Lambert, D; Venbrux, AC; Lund, GB;
Indirizzi:
Johns Hopkins Hosp, Div Cardiovasc & Intervent Radiol, Baltimore, MD 21287USA Johns Hopkins Hosp Baltimore MD USA 21287 Radiol, Baltimore, MD 21287USA Johns Hopkins Hosp, Div Magnet Resonance Res, Baltimore, MD 21287 USA Johns Hopkins Hosp Baltimore MD USA 21287 ce Res, Baltimore, MD 21287 USA Johns Hopkins Hosp, Dept Pathol, Baltimore, MD 21287 USA Johns Hopkins Hosp Baltimore MD USA 21287 Pathol, Baltimore, MD 21287 USA Marshfield Clin, Dept Radiat Oncol, Marshfield, WI USA Marshfield Clin Marshfield WI USA Dept Radiat Oncol, Marshfield, WI USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 10, volume: 11, anno: 2000,
pagine: 1245 - 1255
SICI:
1051-0443(200011/12)11:10<1245:COLTIA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; HEPATOCELLULAR-CARCINOMA; OILY CHEMOEMBOLIZATION; IN-VIVO; EMBOLIZATION; DOXORUBICIN; RESECTION; RAT;
Keywords:
chemoembolization; liver neoplasms, chemotherapeutic infusion; magnetic resonance (MR), diffusion study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Geschwind, JFH Johns Hopkins Hosp, Div Cardiovasc & Intervent Radiol, Blalock 545,600 N Wolfe St, Baltimore, MD 21287 USA Johns Hopkins Hosp Blalock 545,600 N Wolfe St Baltimore MD USA 21287
Citazione:
J.F.H. Geschwind et al., "Chemoembolization of liver tumor in a rabbit model: Assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis", J VAS INT R, 11(10), 2000, pp. 1245-1255

Abstract

PURPOSE: To assess the efficacy of chemoembolization of liver tumors by determining the fraction of viable tumor cells remaining after treatment withuse of diffusion magnetic resonance (MR) imaging and histologic analysis. MATERIALS AND METHODS: VX2 tumor was grown in the livers of 12 rabbits. Animals were divided into a chemoembolization group and an untreated group. Conventional, perfusion, and diffusion MR imaging was performed on all rabbits. Histopathologic analysis of explanted livers was performed to document tumor cell death and measure Bcl-2 levels (inhibitor of apoptosis). RESULTS: Diffusion-weighted MR imaging delineated zones of tumor cell death as regions of lower signal intensity in both groups. Apparent diffusion coefficients were significantly greater in the area of tumor necrosis than in the area of viable tumor. Histologic analysis demonstrated a significantly lower percentage of viable cells in the treated group (<1%) than in the control group (55%). Bcl-2 expression detected within the viable areas of the tumor was greater in the treated group than in the control group. CONCLUSIONS: Chemoembolization causes extensive tumor cell destruction. Diffusion MR imaging can detect tumor cell death and can be used to assess the efficacy of chemoembolization, Bcl-2 was expressed in the treated group, suggesting an apoptotic pathway of cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:28:19