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Titolo:
The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years
Autore:
Rau, R; Herborn, G; Zueger, S; Fenner, H;
Indirizzi:
Evangel Fachkrankenhaus, Rheumaklin, Dept Rheumatol, D-40882 Ratingen, Germany Evangel Fachkrankenhaus Ratingen Germany D-40882 40882 Ratingen, Germany Swiss Fed Inst Technol, Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland Technol, Zurich, Switzerland
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 11, volume: 27, anno: 2000,
pagine: 2566 - 2575
SICI:
0315-162X(200011)27:11<2566:TEOHGR>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GOLD SODIUM THIOMALATE; HLA-DR ANTIGENS; OLIGONUCLEOTIDE PROBES; SHARED-EPITOPE; SEVERITY; ASSOCIATION; SUSCEPTIBILITY; HETEROGENEITY; METHOTREXATE; SUBTYPES;
Keywords:
rheumatoid arthritis; HLA-DRB1 genes; rheumatoid factor; radiographic progression; DMARD treatment; longterm study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Rau, R Evangel Fachkrankenhaus, Rheumaklin, Dept Rheumatol, Rosenstr 2, D-40882 Ratingen, Germany Evangel Fachkrankenhaus Rosenstr 2 Ratingen Germany D-40882 ermany
Citazione:
R. Rau et al., "The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years", J RHEUMATOL, 27(11), 2000, pp. 2566-2575

Abstract

Objective. To investigate the relationship between radiographic disease progression in the presence or absence of rheumatoid arthritis (RA) linked HLA-DRB1 alleles after early introduction of disease modifying antirheumatic drug therapy in patients with RA over a study period of 6 years. Methods. One hundred nine patients of a trial comparing intramuscular(im) gold sodium thiomalate (GSTM) and im methotrexate (MTX) in early erosive RAwere followed for 6 years with regular assessments of clinical and laboratory data and yearly radiographs of hands and feet, and they were typed for HLA-DRB1 genes. Radiographic progression was analyzed for an influence of rheumatoid factor (RF) status and HLA-DRB1 genes. Results. Twenty-seven patients (25%) were positive for two. 46 (42%) for one, and 36 (33%) for none of the disease linked alleles. A decrease of the rate of radiographic disease progression with treatment in this group of patients was reflected by the decline in the slope of the radiographic score. Seropositive patients (n = 71, 68%) had a significantly more destructive disease course than RF negative patients. In seropositive disease, patients with a "double dose" of RA linked alleles showed a tendency to greater progression during the First 12-24 mo of treatment. but no significant difference in the longterm radiographic outcome could be detected between subgroupsdefined by the presence or absence of HLA-DRB1 genes. There was no significant difference throughout the study period with respect to the clinical disease course as assessed by joint swelling, C-reactive protein, and erythrocyte sedimentation rate. The majority of the seronegative population (n = 38, 32%) had a benign disease course with the exception of patients (n = 6) with the double allele; they had radiographic disease progression comparable with the seropositive patients. Conclusion. Our data do not provide evidence fur a more aggressive diseasecourse in patients bearing double RA linked HLA-DRB1 alleles.

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Documento generato il 30/05/20 alle ore 15:13:42