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Titolo:
Three-dimensional topography of corticopontine projections from rat barrelcortex: Correlations with corticostriatal organization
Autore:
Leergaard, TB; Alloway, KD; Mutic, JJ; Bjaalie, JG;
Indirizzi:
Univ Oslo, Inst Basic Med Sci, Dept Anat, N-0317 Oslo, Norway Univ Oslo Oslo Norway N-0317 sic Med Sci, Dept Anat, N-0317 Oslo, Norway Penn State Univ, Dept Anat & Neurosci, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 at & Neurosci, Hershey, PA 17033 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 20, anno: 2000,
pagine: 8474 - 8484
SICI:
0270-6474(20001115)20:22<8474:TTOCPF>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASILAR PONTINE NUCLEI; SOMATIC SENSORY CORTEX; BASAL GANGLIA; SOMATOTOPIC ORGANIZATION; SOMATOSENSORY CORTEX; LATERAL LEMNISCUS; AXONAL-TRANSPORT; DATA-ACQUISITION; CEREBRAL-CORTEX; PRIMARY MOTOR;
Keywords:
3-D reconstruction; basal ganglia; cerebellum; cerebrocerebellar; double anterograde tracing; parallel circuits; pontine nuclei; somatosensory maps; somatotopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Bjaalie, JG Univ Oslo, Inst Basic Med Sci, Dept Anat, POB 1105 Blindern, N-0317 Oslo, Norway Univ Oslo POB 1105 Blindern Oslo Norway N-0317 7 Oslo, Norway
Citazione:
T.B. Leergaard et al., "Three-dimensional topography of corticopontine projections from rat barrelcortex: Correlations with corticostriatal organization", J NEUROSC, 20(22), 2000, pp. 8474-8484

Abstract

Subcortical re-entrant projection systems connecting cerebral cortical areas with the basal ganglia and cerebellum are topographically specific and therefore considered to be parallel circuits or "closed loops. " The precision of projections within these circuits, however, has not been characterizedsufficiently to indicate whether cortical signals are integrated within oramong presumed compartments. To address this issue, we studied the first link of the rat cortico-ponto-cerebellar pathway with anterograde axonal tracing from physiologically defined, individual whisker "barrels" of the primary somatosensory cortex (SI). The labeled axons in the pontine nuclei formed several, sharply delineated clusters. Dual tracer injections into different SI whisker barrels gave rise to partly overlapping, paired clusters, indicating somatotopic specificity. Three-dimensional reconstructions revealed that the clusters were components of concentrically organized lamellar subspaces. Whisker barrels in the same row projected to different pontine lamellae (side by side), the somatotopic representation of which followed an inside-out sequence. By contrast, whisker barrels from separate rows projected to clusters located within the same lamellar subspace (end to end). In the neostriatum, this lamellar topography was the opposite, with barrels in the same row contacting different parts of the same lamellar subspace (end to end). The degree of overlap among pontine clusters varied as a function of the proximity of the cortical injections. Furthermore, corticopontine overlap was higher among projections from barrels in the same row than among projections from different whisker barrel rows. This anisotropy was the same in the corticostriatal projection. These findings have important implications for understanding convergence and local integration in somatosensory-related subcortical circuits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:36:24