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Titolo:
Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep
Autore:
Cape, EG; Manns, ID; Alonso, A; Beaudet, A; Jones, BE;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 20, anno: 2000,
pagine: 8452 - 8461
SICI:
0270-6474(20001115)20:22<8452:NBOCBF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS BASALIS; CEREBRAL-CORTEX; ELECTROENCEPHALOGRAM ACTIVITY; ACETYLCHOLINE OUTPUT; ELECTRICAL-ACTIVITY; CINGULATE CORTEX; RAT; BEHAVIOR; MECHANISMS; MODULATION;
Keywords:
acetylcholine; choline acetyltransferase; EEG; sleep-wake states; slow wave sleep; delta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, BE McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, 3801Univ St, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Univ St Montreal PQCanada H3A 2B4 2B4, Canada
Citazione:
E.G. Cape et al., "Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep", J NEUROSC, 20(22), 2000, pp. 8452-8461

Abstract

Cholinergic basal forebrain neurons have long been thought to play an important role in cortical activation and behavioral state, yet the precise wayin which they influence these processes has yet to be fully understood. Here, we have examined the effects on the electroencephalogram (EEG) and sleep-wake state of basal forebrain administration of neurotensin (NT), a neuropeptide that has been shown in vitro to potently and selectively modulate the cholinergic cells. Microinjection of (0.1-3.0 mM) NT into the basal forebrain of freely moving, naturally waking-sleeping rats produced ka dose-dependent decrease in delta (similar to1-4 Hz) and increase in both theta (similar to4-9 Hz) and high-frequency gamma activity (30-60 Hz) across cortical, areas with no increase in the electromyogram. These EEG changes were accompanied by concomitant decreases in slow wave sleep (SWS) and transitional SWS (tSWS), increases in wake, and most remarkably, increases in paradoxical sleep (PS) and transitional PS (tPS), despite the virtual absence of SWS. The effects were attributed to direct action on cholinergic neurons as evidenced by selective internalization of a fluorescent ligand, Fluo-NT, in choline acetyltransferase (ChAT) immunoreactive cells and stimulation by NT of bursting discharge in juxtacellularly recorded, Neurobiotin-labeled, ChAT-immunoreactive neurons. We conclude that NT-induced rhythmic bursting of cholinergic basal forebrain neurons stimulates rhythmic theta oscillations and gamma across the cerebral cortex. With the selective action of NT on thecholinergic cells, their bursting discharge promotes theta and gamma independent of motor activity and thereby also stimulates and enhances PS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 03:53:00