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Titolo:
Corticolimbic interactions associated with performance on a short-term memory task are modified by age
Autore:
Della-Maggiore, V; Sekuler, AB; Grady, CL; Bennett, PJ; Sekuler, R; McIntosh, AR;
Indirizzi:
Baycrest Ctr, Rotman Res Inst, Toronto, ON M6A 2E1, Canada Baycrest Ctr Toronto ON Canada M6A 2E1 Inst, Toronto, ON M6A 2E1, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 2G3, Canada Univ Toronto Toronto ON Canada M5S 2G3 ychol, Toronto, ON M5S 2G3, Canada Brandeis Univ, Volen Ctr Complex Syst, Waltham, MA 02254 USA Brandeis Univ Waltham MA USA 02254 tr Complex Syst, Waltham, MA 02254 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 20, anno: 2000,
pagine: 8410 - 8416
SICI:
0270-6474(20001115)20:22<8410:CIAWPO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MEDIAL TEMPORAL CORTICES; FUNCTIONAL CONNECTIVITY; PREFRONTAL CORTEX; RECOGNITION MEMORY; NETWORK ANALYSIS; NEURAL SYSTEMS; WORKING-MEMORY; RHESUS-MONKEY; HUMAN BRAIN;
Keywords:
aging; functional connectivity; hippocampus; partial least squares; short-term memory; structural equation modeling; visual memory; plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Della-Maggiore, V Baycrest Ctr, Rotman Res Inst, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada Baycrest Ctr 3560 Bathurst St Toronto ON Canada M6A 2E1
Citazione:
V. Della-Maggiore et al., "Corticolimbic interactions associated with performance on a short-term memory task are modified by age", J NEUROSC, 20(22), 2000, pp. 8410-8416

Abstract

Aging has been associated with a decline in memory abilities dependent on hippocampal processing. We investigated whether the functional interactionsbetween the hippocampus and related cortical areas were modified by age. Young and old subjects' brain activity was measured using positron emission tomography (PET) while they performed a short-term memory task (delayed visual discrimination) in which they determined which of two successively presented sine-wave gratings had the highest spatial frequency. Behavioral performance was equal for the two groups. Partial least squares (PLS) analysis of PET images identified a hippocampal voxel whose activity was similarly correlated with performance across groups. Using this voxel as a seed, a second PLS analysis identified cortical regions functionally connected to the hippocampus. Quantification of the neural interactions with structural equation modeling suggested that a different hippocampal network supported performance in the elderly. Unlike the neural network engaged by the young, which included prefrontal cortex Brodmann's area (BA) 10, fusiform gyrus, and posterior cingulate gyrus, the network recruited by the old included more anterior areas, i.e., dorsolateral prefrontal cortex (BA 9/46), middle cingulate gyrus, and caudate nucleus. Recruitment of a distinct corticolimbic network for visual memory in the elderly suggests that age-related neurobiological deterioration not only results in focal changes but also in the modification of large-scale network operations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:05:53