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Titolo:
Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3)extraneuronal monoamine transporter
Autore:
Wieland, A; Hayer-Zillgen, M; Bonisch, H; Bruss, M;
Indirizzi:
Univ Bonn, Inst Pharmacol & Toxicol, D-53113 Bonn, Germany Univ Bonn Bonn Germany D-53113 harmacol & Toxicol, D-53113 Bonn, Germany
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 10, volume: 107, anno: 2000,
pagine: 1149 - 1157
SICI:
0300-9564(2000)107:10<1149:AOTGSO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGANIC CATION TRANSPORTER; EXPRESSION; CLONING; CELLS; ORGANIZATION; UPTAKE(2);
Keywords:
extraneuronal monoamine transporter; organic cation transporter 3; solute carrier family; gene structure; exon-intron organization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bonisch, H Univ Bonn, Inst Pharmacol & Toxicol, Reuterstr 2B, D-53113 Bonn, Germany Univ Bonn Reuterstr 2B Bonn Germany D-53113 3113 Bonn, Germany
Citazione:
A. Wieland et al., "Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3)extraneuronal monoamine transporter", J NEURAL TR, 107(10), 2000, pp. 1149-1157

Abstract

The organic cation transporter 3 (OCT3), also termed as extraneuronal monoamine transporter (EMT), is known to be expressed in glial cells where it is responsible for the uptake of catecholamines and neurotoxic organic cations such as 1-methyl-4-phenylpyridinium (MPP+). We have now analyzed the structure of the human and murine OCT3 gene. The coding regions of both genes consist of 11 exons and 10 introns. All exon-intron junctions contain fullyconserved gt/ag consensus splice sites. The human introns are without exception larger than their murine counterparts. In both genes, the introns, apart from intron 1, are located at the same position. Mouse and human exons have the same size with exception of exon 1 which is 15 bp larger in the human gene. The organization of the human OCT3 gene also shows pronounced similarities with other genes of human organic cation transporters such as those for hOCT1, hOCTN2, hORCTL3, and hORCTL4. The genes of these transportersshare about the same exon-intron structure and exon sizes, indicating thatthe genes may have evolved from a common anchestor gene through duplication. Knowledge of the human gene structure of the OCT3 should enable investigations of possible polymorphisms and their involvement in e.g. psychiatric disorders; and knowledge of the mouse exon-intron organization is essentialfor generating a knock-out mouse which should help to recognize the physiological importance of the OCT3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:21:44