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Titolo:
Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice
Autore:
Yu, L; Liao, PC;
Indirizzi:
Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 Behav Med, Tainan 70101, Taiwan Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 upat Hlth, Tainan 70101, Taiwan
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 10, volume: 107, anno: 2000,
pagine: 1139 - 1147
SICI:
0300-9564(2000)107:10<1139:EAPDMM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED NEUROTOXICITY; MONOAMINE-OXIDASE-A; STRIATAL DOPAMINE; SEXUAL DIFFERENCES; OXIDATIVE STRESS; RAT-BRAIN; RELEASE; MICRODIALYSIS; TISSUE; SENSITIVITY;
Keywords:
gender; ovarian hormones; catecholamines; indolamines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, L Natl Cheng Kung Univ, Coll Med, Inst Behav Med, 1 Univ Rd, Tainan 70101, Taiwan Natl Cheng Kung Univ 1 Univ Rd Tainan Taiwan 70101 an 70101, Taiwan
Citazione:
L. Yu e P.C. Liao, "Estrogen and progesterone distinctively modulate methamphetamine-induced dopamine and serotonin depletions in C57BL/6J mice", J NEURAL TR, 107(10), 2000, pp. 1139-1147

Abstract

Intra-striatal infusion of a high dose (100 mug/3 mul) of methamphetamine produced long-lasting depletions of striatal dopamine and serotonin in bothmale and female mice. Male mice exhibited a greater depletion of striatal dopamine and serotonin than female mice. A similar trend of sexual differences was observed when 4 cumulative doses of methamphetamine were administered systemically. Thus, the sexual differences in methamphetamine-induced neurotoxicity in the striatum are probably not due to their differences in peripheral metabolism of methamphetamine. Moreover, ovariectomized (OVX) micesupplemented with 3 daily doses of estradiol benzoate (EB) at high or physiological levels, 3 daily doses of progesterone (P), and 2 doses of EB followed by 1 dose of P all demonstrated higher striatal dopamine levels following methamphetamine treatment as compared to vehicle-supplemented controls. The OVX mice pretreated with 3 daily doses of P exhibited the highest striatal serotonin levels after methamphetamine administration of all groups. In conclusion, sexual differences observed in methamphetamine-induced striatal neurotoxicity may be modulated by ovarian hormones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:22:29