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Titolo:
How fast are antidepressants?
Autore:
Gelenberg, AJ; Chesen, CL;
Indirizzi:
Univ Arizona, Hlth Sci Ctr, Dept Psychiat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Ctr, Dept Psychiat, Tucson, AZ 85724 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 10, volume: 61, anno: 2000,
pagine: 712 - 721
SICI:
0160-6689(200010)61:10<712:HFAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; MAJOR DEPRESSIVE DISORDER; PLACEBO-CONTROLLED TRIAL; TRUE DRUG RESPONSE; DOUBLE-BLIND; PATTERN-ANALYSIS; ELECTROCONVULSIVE-THERAPY; ONSET; EFFICACY; IMIPRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gelenberg, AJ Univ Arizona, Hlth Sci Ctr, Dept Psychiat, POB 245002, Tucson, AZ 85724 USA Univ Arizona POB 245002 Tucson AZ USA 85724 on, AZ 85724 USA
Citazione:
A.J. Gelenberg e C.L. Chesen, "How fast are antidepressants?", J CLIN PSY, 61(10), 2000, pp. 712-721

Abstract

Background: For years, investigators have tried to determine the speed of onset of antidepressant drugs. Claims that particular drugs may produce a faster response in patients than other agents have been made, but such claims have never been confirmed. Method: The authors reviewed reports from studies of the speed of onset ofantidepressant therapies and other studies that revealed information on this topic. We compiled a list of factors that can affect the results of suchstudies and interpretations of study results. In addition, we reviewed literature concerned with methods of speeding up antidepressant responses. Results: No antidepressant medication currently available has been shown conclusively to have a more rapid onset of action than any other. However, some methods of augmentation may have the potential to speed responses. Somatic therapies such as electroconvulsive therapy, phototherapy, and therapeutic sleep deprivation may be the fastest options available at this time. Conclusion: All available antidepressant medications are usually taken forseveral weeks before future responders will display a significant therapeutic benefit. If a patient does not show at least a 20% improvement within the first 2 to 4 weeks of treatment, the treatment regimen should be altered. For patients who do show early benefits from a medication trial, one can expect additional benefits to accrue over an 8- to 12-week period and to improve overall outcome compared with those slower to respond. Future trials need to address methodological confounds, but a truly "faster antidepressant" will probably require new neuroscience technology.

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Documento generato il 14/07/20 alle ore 03:00:06