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Titolo:
Prediction of acute embolic stroke outcome after local intraarterial thrombolysis: Value of pretreatment and posttreatment Tc-99m-ethyl cysteinate dimer single photon emission computed tomography
Autore:
Ogasawara, K; Ogawa, A; Doi, M; Konno, H; Suzuki, M; Yoshimoto, T;
Indirizzi:
Iwate Med Univ, Dept Neurosurg, Morioka, Iwate 0208505, Japan Iwate Med Univ Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan Iwate Med Univ, Cyclotron Res Ctr, Morioka, Iwate 0208505, Japan Iwate MedUniv Morioka Iwate Japan 0208505 Morioka, Iwate 0208505, Japan Tohoku Univ, Sch Med, Dept Neurosurg, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 Neurosurg, Sendai, Miyagi 980, Japan
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 11, volume: 20, anno: 2000,
pagine: 1579 - 1586
SICI:
0271-678X(200011)20:11<1579:POAESO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; ACUTE CEREBRAL INFARCTION; FIBRINOLYTIC THERAPY; CAROTID TERRITORY; EARLY REPERFUSION; TISSUE; SPECT; TPA; RECANALIZATION; PROUROKINASE;
Keywords:
cerebral embolism; Tc-99m-ECD; SPECT; thrombolytic therapy; hemorrhagic transformation; stroke management;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ogasawara, K Iwate Med Univ, Dept Neurosurg, 19-1 Uchimaru, Morioka, Iwate0208505, Japan Iwate Med Univ 19-1 Uchimaru Morioka Iwate Japan 0208505 apan
Citazione:
K. Ogasawara et al., "Prediction of acute embolic stroke outcome after local intraarterial thrombolysis: Value of pretreatment and posttreatment Tc-99m-ethyl cysteinate dimer single photon emission computed tomography", J CEREBR B, 20(11), 2000, pp. 1579-1586

Abstract

The aim of this study was to investigate the efficacy of pre- and posttreatment Tc-99m-ethyl cysteinate dimer (Tc-99m-ECD) single photon emission computed tomography (SPECT) for predicting the ischemic outcome of embolic middle cerebral artery occlusion after treatment with local intraarterial thrombolysis. The authors examined 28 patients with a moderately ischemic area (ratio of affected regional activity to cerebellar activity (A/C ratio) of 0.4 to 0.7) determined using pretreatment SPECT, and with complete recanalization within 6 hours. Posttreatment dynamic and static SPECT studies were performed immediately after thrombolysis. The extent of the affected area outlined on pretreatment SPECT was used for the posttreatment SPECT images, and AIC ratios were calculated. The relative retention ratio of Tc-99m-ECD in the affected area was also analyzed using posttreatment dynamic SPECT. Four-teen patients either without infarction or with small subcortical and basal ganglial infarction, 11 patients with medium or large cortical infarction, and 3 patients with hemorrhage were identified by follow-up computed tomography. Ischemic outcome correlated with the relative retention ratio ofTc-99m-ECD more closely than either the pre- or posttreatment A/C ratios. In particular, a threshold value for the development of hemorrhage was distinct only in the relative retention ratio of Tc-99m-ECD. Pretreatment Tc-99m-ECD SPECT did not always predict the occurrence of hemorrhagic transformation, whereas dynamic Tc-99m-ECD SPECT performed immediately after thrombolysis allowed clear identification of patients at risk for hemorrhagic transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:02:57