Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Persistent infection mechanism of GB virus C hepatitis G virus differs from that of hepatitis C virus
Autore:
Orii, K; Tanaka, E; Rokuhara, A; Maruyama, A; Ichijo, T; Yoshizawa, K; Kiyosawa, K;
Indirizzi:
Shinshu Univ, Sch Med, Dept Internal Med 2, Matsumoto, Nagano 3908621, Japan Shinshu Univ Matsumoto Nagano Japan 3908621 sumoto, Nagano 3908621, Japan
Titolo Testata:
INTERVIROLOGY
fascicolo: 3, volume: 43, anno: 2000,
pagine: 139 - 145
SICI:
0300-5526(200005/06)43:3<139:PIMOGV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-B-HEPATITIS; DISEASE ASSOCIATION; ENVELOPE PROTEIN; NON-A; ANTIBODY; TRANSFUSION; GENOME; GLYCOPROTEIN; CLONING; REGION;
Keywords:
GB virus C; hepatitis G virus; hepatitis C virus; hypervarjable region; loop domain; persistent infection; envelope 2 region; amino acid substitution; nucleotide substitution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, E Shinshu Univ, Sch Med, Dept Internal Med 2, 3-1-1 Asahi, Matsumoto, Nagano3908621, Japan Shinshu Univ 3-1-1 Asahi Matsumoto Nagano Japan 3908621 1, Japan
Citazione:
K. Orii et al., "Persistent infection mechanism of GB virus C hepatitis G virus differs from that of hepatitis C virus", INTERVIROLO, 43(3), 2000, pp. 139-145

Abstract

Objective: Changes in the deduced amino acid sequence of the envelope 2 (E2) region of the GB virus C/hepatitis G virus (GBV-C/HGV) were analyzed to investigate whether or not the region contributes to persistent infection with the virus. Methods: Eight patients with acute hepatitis C and 1 patientwith acute hepatitis of unknown etiology were included in the study. GBV-C/HGV RNA was detected in 6 patients, including the patient with hepatitis of unknown origin. The nucleotide sequence of the E2 region of hepatitis C virus (HCV) and GBV-C/HGV was determined by direct sequencing of polymerase chain reaction products in 5 patients with HCV infection and in 6 patients with GBV-C/HGV infection twice during the period of early infection and several months or years later in each patient, Results:The mean substitution rate of the deduced amino acid sequence in the E2 region was over 100 times lower (p < 0.001) in GBV-C/HGV (0.01 +/- 0.04/month/100 sites) than in HCV (2.4 +/- 1.7/month/100 sites), The amino acid sequence of the loop domain of GBV-C/HGV-E2 did not change in any of the 6 patients. On the other hand, the sequence of the hypervariable region of HCV-E2 changed remarkably (5.9 /- 4,3/month/ 100 sites). No am ino acid substitution in the loop domain was observed in 7 additional patients who showed persistent GBV-C/HGV viremia for more than 2 years. Conclusion: These results indicate that changes inthe amino acid sequence of the E2 region are not involved in the mechanismof persistent GEV-C/HGV infection. Copyright (C) 2000 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:55:24