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Titolo:
Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis
Autore:
DAgostini, F; Balansky, RM; Camoirano, A; De Flora, S;
Indirizzi:
Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 enoa, Dept Hlth Sci, I-16132 Genoa, Italy Natl Oncol Ctr, Sofia, Bulgaria Natl Oncol Ctr Sofia BulgariaNatl Oncol Ctr, Sofia, Bulgaria
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 88, anno: 2000,
pagine: 702 - 707
SICI:
0020-7136(200012)88:5<702:IBNAAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LUNG-TUMORS; ETHYL CARBAMATE; GENE-EXPRESSION; VINYL CARBAMATE; MESSENGER-RNA; INHIBITION; MICE; MUTAGENICITY; ANTIOXIDANT; GLUTATHIONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: De Flora, S Univ Genoa, Dept Hlth Sci, Via A Pastore 1, I-16132 Genoa, Italy Univ Genoa Via A Pastore 1 Genoa Italy I-16132 2 Genoa, Italy
Citazione:
F. D'Agostini et al., "Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis", INT J CANC, 88(5), 2000, pp. 702-707

Abstract

Both ascorbic acid (AsA, vitamin C) and N-acetylcysteine (NAC), a precursor and analogue of glutathione, possess a broad array of biological properties underlying their protective role in a variety of pathophysiological conditions. However, under certain circumstances, AsA behaves as a prooxidant rather than an anti-oxidant and produces adverse effects. This prompted us to evaluate whether NAC could interact with AsA in preventing mutation and cancer. AsA significantly increased spontaneous revertants in the Solmonellotyphimurium strains TA102 and TA104, which are sensitive to oxidative mutagens. In contrast, NAC lowered the spontaneous background in TA104 and neutralized the negative effects of AsA. Moreover, NAC and AsA showed additive effects in reducing chromium(VI) and in reverting its mutagenicity. A single i.p. injection of urethane (1 g/kg body weight) to 120 A/J mice resulted,after 4 months, in the formation of a total of 1,532 lung tumors, 425 in the 30 mice treated with the carcinogen only, 404 in those treated with urethane plus AsA, 365 in those treated with urethane plus NAC and 338 in thosetreated with urethane plus the combination of AsA and NAC (both given daily with drinking water at the dose of 1 g/kg body weight). Compared to positive controls, tumor multiplicity was poorly affected by AsA, whereas it wassignificantly decreased by NAC and even more so by its combination with AsA. The overall volumes of lung tumors in the 4 groups were 107.5, 89.3, 61.3 and 49.7 mm(3), respectively. Tumor sizes were slightly but significantlydecreased in mice treated with AsA and more so in those treated with NAC and NAC plus AsA, their combination being significantly more effective than each individually. AII protective effects elicited by combining the 2 drugswere additive. Therefore, NAC prevents the adverse effects of AsA on spontaneous mutagenicity; at the same time, this thiol behaves in an additive fashion with AsA, inhibiting the mutagenicity of chromium(VI) and the lung tumorigenicity of urethane in mice. These findings suggest that NAC and AsA could conveniently be combined in cancer chemoprevention and other pharmacological interventions. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:07:26