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Titolo:
The association of infection and coronary artery disease: an update
Autore:
Davydov, L; Cheng, JWM;
Indirizzi:
Mt Sinai Med Ctr, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA10029 ai Med Ctr, New York, NY 10029 USA
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 11, volume: 9, anno: 2000,
pagine: 2505 - 2517
SICI:
1354-3784(200011)9:11<2505:TAOIAC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLAMYDIA-PNEUMONIAE INFECTION; ACUTE MYOCARDIAL-INFARCTION; PRIOR CYTOMEGALOVIRUS-INFECTION; HELICOBACTER-PYLORI INFECTION; HUMAN ATHEROSCLEROTIC PLAQUES; ABDOMINAL AORTIC-ANEURYSMS; POLYMERASE-CHAIN-REACTION; HUMAN ENDOTHELIAL-CELLS; ISCHEMIC-HEART-DISEASE; RABBIT MODEL;
Keywords:
atherosclerosis; chlamydia; coronary artery disease; cytomegalovirus; helicobacter pylori;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Cheng, JWM Mt Sinai Med Ctr, Box 1211,1 Gustave L Levy Pl, New York, NY 10029 USA Mt Sinai Med Ctr Box 1211,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
L. Davydov e J.W.M. Cheng, "The association of infection and coronary artery disease: an update", EXPERT OP I, 9(11), 2000, pp. 2505-2517

Abstract

Numerous studies have reported an association of coronary atherosclerosis and restenosis with certain bacterial and viral infections. This article reviews the pathophysiology of atherosclerosis, the role of infectious agents(cytomegalovirus, Chlamydia pneumoniae and Helicobacter pylori) in atherogenesis and studies supporting the potential beneficial effects of antibiotics or antiviral agents in the management of atherosclerotic disease. The interactions of cytomegalovirus and the arterial wall have been extensively studied. However, despite the successful preliminary therapeutic trials withthe use of macrolides in augmenting possible C. pneumoniae-induced cardiovascular events, the exact mechanisms of how C. pneumoniae enters the arterial wall remains unknown at this point. For H. pylori, regardless of the large number of studies performed to assess the association between H. pylori and coronary artery disease, no definitive conclusion could be made at thistime, due to contradictory results. Before one can widely adopt the use ofantibiotics or antiviral agents as treatment for atherosclerosis, further studies must be designed to address some important issues. In vivo animal models need to be established to further examine the various hypotheses regarding the interaction of infectious agents and atherosclerosis and restenosis. Large-scale prospective cohort studies should be designed to relate evidence of infection to future risk of cardiovascular diseases. Confounding variables, such as other cardiovascular risk factors and socio-economic status, should be controlled in order to strengthen the association. Further interventional studies are also required to establish the best antibiotic or antiviral regimen to maximise efficacy and minimise side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:58:15