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Titolo:
Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow
Autore:
Khan, GM; Smolders, I; Ebinger, G; Michotte, Y;
Indirizzi:
Free Univ Brussels, Dept Pharmaceut Chem & Drug Anal, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 nal, B-1090 Brussels, Belgium Free Univ Brussels, Dept Neurol, B-1090 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1090 rol, B-1090 Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 407, anno: 2000,
pagine: 139 - 144
SICI:
0014-2999(20001027)407:1-2<139:FPDAAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PILOCARPINE-INDUCED SEIZURES; GAMMA-AMINOBUTYRIC-ACID; FREELY MOVING RATS; AMINO-ACIDS; INHIBITION; RELEASE; GABA; HIPPOCAMPAL; MICRODIALYSIS; RECEPTORS;
Keywords:
glutamate; diazepam; flumazenil; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Michotte, Y Free Univ Brussels, Dept Pharmaceut Chem & Drug Anal, Laarbeeklaan 103, B-1090 Brussels, Belgium Free Univ Brussels Laarbeeklaan 103 Brussels Belgium B-1090 m
Citazione:
G.M. Khan et al., "Flumazenil prevents diazepam-elicited anticonvulsant action and concomitant attenuation of glutamate overflow", EUR J PHARM, 407(1-2), 2000, pp. 139-144

Abstract

Systemic administration of diazepam (5 mg/kg, i.p.) produced a prompt anticonvulsant effect in pilocarpine-induced seizures in freely moving rats. The anticonvulsant effect was associated with significant attenuation of pilocarpine-evoked increases in extracellular hippocampal glutamate levels to below the baseline levels. The purpose of the present microdialysis study, therefore, was to investigate if the effect of diazepam on glutamate releasewas mediated at the level of the benzodiazepine gamma -aminobutyric acid(A) (GABA(A)) receptor complex to preclude any non-GABAergic mechanisms. Systemic administration of the specific benzodiazepine-receptor antagonist flumazenil (10 mg/kg, i.p.)-elicited complete reversal of diazepam-evoked anticonvulsant action and concomitant attenuation of extracellular glutamate efflux below the baseline levels. This provides evidence that under the given experimental conditions, diazepam-evoked alterations in glutamate overflow associated with the anticonvulsant action were indeed mediated at the levelof benzodiazepine-GABA(A) receptor complex, possibly involving the modulation of both pre- and post-synaptic sites of the receptor complex. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 04:56:33