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Titolo:
Activation of the retrohippocampal region in the rat causes dopamine release in the nucleus accumbens: disruption by fornix section
Autore:
Mitchell, SN; Yee, BK; Feldon, J; Gray, JA; Rawlins, JNP;
Indirizzi:
Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England Univ Oxford Oxford England OX1 3UD Expt Psychol, Oxford OX1 3UD, England Swiss Fed Inst Technol, Behav Biol Lab, CH-8603 Schwerzenbach, SwitzerlandSwiss Fed Inst Technol Schwerzenbach Switzerland CH-8603 ch, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 407, anno: 2000,
pagine: 131 - 138
SICI:
0014-2999(20001027)407:1-2<131:AOTRRI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; VENTRAL HIPPOCAMPUS; PREFRONTAL CORTEX; ANTEROGRADE TRANSPORT; LOCOMOTOR-ACTIVITY; SCHIZOPHRENIA; PROJECTIONS; SUBICULUM; STRIATUM; NEURONS;
Keywords:
dopamine; subiculum; nucleus accumbens; fimbria-fornix; microdialysis; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Mitchell, SN Eli Lilly & Co, Lilly Res Ctr Ltd, Erl Wood Manor, WindleshamGU20 6PH, Surrey, England Eli Lilly & Co Erl Wood Manor Windlesham Surrey England GU20 6PH
Citazione:
S.N. Mitchell et al., "Activation of the retrohippocampal region in the rat causes dopamine release in the nucleus accumbens: disruption by fornix section", EUR J PHARM, 407(1-2), 2000, pp. 131-138

Abstract

There is a well-described projection from the retrohippocampus (subiculum and entorhinal cortex) to the nucleus accumbens that is involved in the control of psychomotor behaviour, and is implicated in the aetiology of schizophrenia Cortical abnormalities are widely reported in the brains of schizophrenic patients, but it is unclear whether they are the cause or consequence of those changes in subcortical systems that are treated with neurolepticdrugs. We have, therefore, conducted a series of microdialysis experimentsin anaesthetized rats to determine whether infusion of the excitotoxin, N-methyl-D-aspartate, into the retrohippocampus increases mesolimbic dopaminerelease. We found a clear and reproducible increase in extracellular dopamine in the nucleus accumbens following N-methyl-D-aspartate (2.5 mug), thatwas abolished when we sectioned the fimbria-fornix. Furthermore, inhibition of gamma -aminobutyric acid receptors following retrohippocampus administration of bicuculline (4 mug), also increased dopamine in the nucleus accumbens. The dopamine response to bicuculline was accompanied by an increase in dopamine metabolism, was long lasting, and also reduced by fornix section. The response to both N-methyl-D-aspartate and bicuculline depends on the integrity of the pi-ejection from the retrohippocampus to the nucleus accumbens. The results provide an underlying mechanism whereby a primary insult in the temporal cortex, caused by excessive N-methyl-D-aspartate receptor stimulation, can produce a hyperdopaminergic state. In addition, an increase in subiculo-accumbens activity evoked by bicuculline may also explain why patients with limbic epilepsy can develop a psychosis. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:56:52