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Titolo:
Different outcomes after acute and chronic treatment with nicotine in pre-pulse inhibition in Lister hooded rats
Autore:
Mirza, NR; Misra, A; Bright, JL;
Indirizzi:
Vernalis PLC, Dept Neuropharmacol, Woking RG41 5UA, Surrey, England Vernalis PLC Woking Surrey England RG41 5UA ing RG41 5UA, Surrey, England Vernalis PLC, Dept Mol Pharmacol, Woking RG41 5UA, Surrey, England Vernalis PLC Woking Surrey England RG41 5UA ing RG41 5UA, Surrey, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 407, anno: 2000,
pagine: 73 - 81
SICI:
0014-2999(20001027)407:1-2<73:DOAAAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS DOPAMINE; PREPULSE INHIBITION; STARTLE REFLEX; SCHIZOPHRENIC-PATIENTS; LOCOMOTOR-ACTIVITY; LATENT INHIBITION; BINDING-SITES; ANIMAL-MODEL; BRAIN; AMPHETAMINE;
Keywords:
(rat); nicotine; pre-pulse inhibition; schizophrenia; information processing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Mirza, NR Vernalis PLC, Dept Neuropharmacol, Oakdene Court,613 Reading Rd,Woking RG41 5UA, Surrey, England Vernalis PLC Oakdene Court,613 Reading RdWoking Surrey England RG41 5UA
Citazione:
N.R. Mirza et al., "Different outcomes after acute and chronic treatment with nicotine in pre-pulse inhibition in Lister hooded rats", EUR J PHARM, 407(1-2), 2000, pp. 73-81

Abstract

Excessive tobacco consumption by schizophrenic patients may be a form of self-medication, and nicotine in tobacco may alleviate deficits in information processing. We tested this hypothesis by deter-mining whether nicotine (acute/chronic) would improve information processing in the rat using pre-pulse inhibition as a model. In study 1, rats were injected with nicotine 10 min prior to placement in startle chambers (0.001-0.1 or 0.03-0.3 mg/kg, s.c.). In study 2, rats were injected with either saline or nicotine (0.4 mg/kg, s.c.) for 21 consecutive days and assessed for locomotor activity, pre-pulse inhibition and changes in [H-3]nicotine binding in whole brain. Acutely, nicotine had no effect on pre-pulse inhibition. By contrast, after chronic nicotine treatment, rats demonstrated a robust deficit in pre-pulse inhibition and significant increases in locomotor activity and [H-3]nicotine binding. The deficit in pre-pulse inhibition after chronic treatment with nicotine may be the result of non-specific behavioural activation due to increased mesolimbic dopamine release or, possibly, nicotine may rapidly desensitize nicotinic receptors important for normal information processing. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:03:35