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Titolo:
Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients
Autore:
Ozdag, H; Tez, M; Sayek, I; Muslumanoglu, M; Tarcan, O; Icli, F; Ozturk, M; Ozcelik, T;
Indirizzi:
Bilkent Univ, Dept Mol Biol & Genet, TR-06533 Ankara, Turkey Bilkent UnivAnkara Turkey TR-06533 iol & Genet, TR-06533 Ankara, Turkey Hacettepe Univ, Sch Med, Dept Surg, TR-06100 Ankara, Turkey Hacettepe Univ Ankara Turkey TR-06100 Dept Surg, TR-06100 Ankara, Turkey Istanbul Univ, Dept Surg, Istanbul Med Sch, TR-34080 Istanbul, Turkey Istanbul Univ Istanbul Turkey TR-34080 ed Sch, TR-34080 Istanbul, Turkey Ankara Oncol Hosp, TR-06200 Ankara, Turkey Ankara Oncol Hosp Ankara Turkey TR-06200 l Hosp, TR-06200 Ankara, Turkey Ankara Univ, Sch Med, Dept Med Oncol, TR-06100 Ankara, Turkey Ankara UnivAnkara Turkey TR-06100 pt Med Oncol, TR-06100 Ankara, Turkey
Titolo Testata:
EUROPEAN JOURNAL OF CANCER
fascicolo: 16, volume: 36, anno: 2000,
pagine: 2076 - 2082
SICI:
0959-8049(200010)36:16<2076:GLBABG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN-CANCER; SUSCEPTIBILITY GENE; POPULATION; FAMILIES;
Keywords:
hereditary breast/ovarian cancer; BRAC1; BRAC2; germ line mutation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ozcelik, T Bilkent Univ, Dept Mol Biol & Genet, TR-06533 Ankara, Turkey Bilkent Univ Ankara Turkey TR-06533 , TR-06533 Ankara, Turkey
Citazione:
H. Ozdag et al., "Germ line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients", EUR J CANC, 36(16), 2000, pp. 2076-2082

Abstract

Germ line BRCA1 and/or BRCA2 mutations were screened in 50 Turkish breast and/or ovarian cancer patients composed of hereditary. familial, early onset and male cancer groups. Genomic DNA samples were tested by heteroduplex analysis and DNA sequencing. Two truncating BRCA2 mutations, one novel (6880insG) and one previously reported (3034 delAAAC), were found in two out Ofsix (33%)) hereditary breast and or ovarian cancer patients. A novel truncating (1200 insA) and a missense (2080A-->G) BRCA1 mutation was found in two of 27 (7%) individuals in the early onset group. A total of four (8%) disease-causing mutations in 50 breast cancer patients were identified in BRCA1 and BRCA2 genes. In addition, five BRCA1 sequence variants have been identified in 23 patients. These results indicate that BRCA1 and BRCA2 genes are involved in some, but not all, forms of hereditary predisposition to breast cancer in the Turkish population. (C) 2000 Published by Elsevier ScienceLtd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:25:46