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Titolo:
Thermogenic drugs as a strategy for treatment of obesity
Autore:
Astrup, A;
Indirizzi:
RVA Univ Copenhagen, Res Dept Human Nutr, DK-1958 Frederiksberg C, DenmarkRVA Univ Copenhagen Frederiksberg Denmark C 958 Frederiksberg C, Denmark
Titolo Testata:
ENDOCRINE
fascicolo: 2, volume: 13, anno: 2000,
pagine: 207 - 212
SICI:
1355-008X(200010)13:2<207:TDAASF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL LEPTIN DEFICIENCY; 24-HOUR ENERGY-EXPENDITURE; BODY-COMPOSITION; BETA(3)-ADRENOCEPTOR AGONISTS; RECOMBINANT LEPTIN; EPHEDRINE; SIBUTRAMINE; CAFFEINE; HUMANS; TRIAL;
Keywords:
beta-agonists; thermogenesis; obesity treatment; thyroid hormone; uncoupling protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Astrup, A RVA Univ Copenhagen, Res Dept Human Nutr, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark RVA Univ Copenhagen Rolighedsvej 30 Frederiksberg Denmark C ark
Citazione:
A. Astrup, "Thermogenic drugs as a strategy for treatment of obesity", ENDOCRINE, 13(2), 2000, pp. 207-212

Abstract

There is accumulating evidence to support the hypothesis that a low-energy-output phenotype is at high risk of weight gain and obesity, irrespective of whether this is owing to a low vesting metabolic rate and/or physical inactivity. The low-energy-output phenotype is associated with impaired appetite control, which is improved if energy output is increased. This is the background for pharmacologic stimulation of energy expenditure as a tool to improve the results of obesity management. Targets are the leptin receptors, the sympathetic nervous system and its peripheral beta -adrenoceptors, selective thyroid hormone derivatives, and stimulation of the mitochondrial uncoupling proteins, Currently available compounds such as recombinant leptin, ephedrine/caffeine, and sibutramine possess thermogenic properties owingto their activation of the sympathoadrenal system. Compounds acting selectively on the human beta (3)-adrenoceptor are still promising tools to achieve a sustained stimulation of lipolysis and energy expenditure, and severalare in the pipeline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:53:28