Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
Autore:
Leimeister, C; Dale, K; Fischer, A; Klamt, B; de Angelis, MH; Radtke, F; McGrew, MJ; Pourquie, O; Gessler, M;
Indirizzi:
Univ Wurzburg, Theodor Boveri Inst Bioctr, Inst Physiol Chem 1, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 Chem 1, D-97074 Wurzburg, Germany Univ Mediterranee AP Marseille, INSERM, CNRS, UMR 6545,LGPD,Dev Biol Inst Marseille, F-13288 Marseille 9, France Univ Mediterranee AP Marseille Marseille France 9 88 Marseille 9, France GSF, Inst Expt Genet, D-85764 Neuherberg, Germany GSF Neuherberg GermanyD-85764 t Expt Genet, D-85764 Neuherberg, Germany Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland Ludwig Inst Canc ResEpalinges Switzerland CH-1066 palinges, Switzerland
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 227, anno: 2000,
pagine: 91 - 103
SICI:
0012-1606(20001101)227:1<91:OEOCIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX FACTORS; SOMITE BOUNDARY FORMATION; LUNATIC FRINGE; DROSOPHILA HAIRY; PROTEIN FAMILY; SPLIT; ENHANCER; SOMITOGENESIS; VERTEBRATE; MOUSE;
Keywords:
Hey1; Hey2; c-hairy1; bHLH; Notch signaling; segmentation clock; somitogenesis; PSM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Gessler, M Univ Wurzburg, Theodor Boveri Inst Bioctr, Inst Physiol Chem 1,Hubland, D-97074 Wurzburg, Germany Univ Wurzburg Hubland Wurzburg GermanyD-97074 rzburg, Germany
Citazione:
C. Leimeister et al., "Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors", DEVELOP BIO, 227(1), 2000, pp. 91-103

Abstract

Vertebrate somitogenesis comprises the generation of a temporal periodicity, the establishment of anteroposterior compartment identity, and the translation of the temporal periodicity into the metameric pattern of somites. Molecular players at each of these steps are beginning to be identified. Especially, members of the Notch signaling cascade appear to be involved in setting up the somitogenesis clock and subsequent events. We had previously demonstrated specific expression of the mHey1 and mHey2 basic helix-loop-helix (bHLH) factors during somitogenesis. Here we show that perturbed Notch signaling in Dll1 and Notch1 knockout mutants affects this expression in thepresomitic mesoderm (PSM) and the somites. In the caudal PSM, however, mHey2 expression is maintained and thus is likely to be independent of Notch signaling. Furthermore, we analysed the dynamic expression of the respectivechicken c-Hey1 and c-Hey2 genes during somitogenesis. Not only is c-Hey2 rhythmically expressed across the chicken presomitic mesoderm like c-hairy1,but its transcription is similarly independent of de novo protein synthesis. In contrast, the dynamic expression of c-Hey1 is restricted to the anterior segmental plate. Both c-Hey genes are coexpressed with c-hairy1 in the posterior somite half. further in vitro and in vivo interaction assays demonstrated direct homo- and heterodimerisation between these hairy-related bHLH proteins, suggesting a combinatorial action in both the generation of a temporal periodicity and the anterior-posterior somite compartmentalisation. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:00:37