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Titolo:
COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs
Autore:
Moore, BC; Simmons, DL;
Indirizzi:
Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA Brigham YoungUniv Provo UT USA 84602 Chem & Biochem, Provo, UT 84602 USA
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 11, volume: 7, anno: 2000,
pagine: 1131 - 1144
SICI:
0929-8673(200011)7:11<1131:CIAACB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL ADENOMATOUS POLYPOSIS; COLON-CANCER CELLS; SPONTANEOUS INTESTINAL ADENOMAS; PROSTAGLANDIN-G/H SYNTHASE-1; CHICKEN-EMBRYO FIBROBLASTS; NSAID-INDUCED APOPTOSIS; NITRIC-OXIDE SYNTHASE; MIN MOUSE MODEL; ANTIINFLAMMATORY DRUGS; CYCLOOXYGENASE-2 EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
107
Recensione:
Indirizzi per estratti:
Indirizzo: Simmons, DL Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA Brigham Young Univ Provo UT USA 84602 em, Provo, UT 84602 USA
Citazione:
B.C. Moore e D.L. Simmons, "COX-2 inhibition, apoptosis, and chemoprevention by nonsteroidal anti-inflammatory drugs", CURR MED CH, 7(11), 2000, pp. 1131-1144

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have as their common mechanism the inhibition of cyclooxygenase (COX) enzymes, of which two isoforms (COX-1 and COX-2) exist. The effect of NSAIDs on chemoprevention and tumor regression has been shown in animal models, epidemiologic studies, and in treatment of patients. The exact biochemical and cellular mechanisms underlying each of these phenomena is only partially understood. Processes that have been recently implicated as being important include the inhibition of tumor cell growth, prevention of angiogenesis, and induction of apoptosis in neoplastic cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:21:31