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Titolo:
Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
Autore:
Crosby, JR; Kaminski, WE; Schatteman, G; Martin, PJ; Raines, EW; Seifert, RA; Bowen-Pope, DF;
Indirizzi:
Univ Washington, Hlth Sci Ctr, Dept Pathol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pathol, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA
Titolo Testata:
CIRCULATION RESEARCH
fascicolo: 9, volume: 87, anno: 2000,
pagine: 728 - 730
SICI:
0009-7330(20001027)87:9<728:ECOHOM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGENITOR CELLS; ANALYSIS REVEALS; NEOVASCULARIZATION; VASCULOGENESIS;
Keywords:
hematopoietic stem cell; angiogenesis; endothelial cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Bowen-Pope, DF Univ Washington, Hlth Sci Ctr, Dept Pathol, Box 357470,RoomD525, Seattle,WA 98195 USA Univ Washington Box 357470,Room D525 Seattle WAUSA 98195 A
Citazione:
J.R. Crosby et al., "Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation", CIRCUL RES, 87(9), 2000, pp. 728-730

Abstract

Granulation tissue formation is an example of new tissue development in anadult. its rich vascular network has been thought to derive via angiogenicsprouting and extension of preexisting vessels from the surrounding tissue. The possibility that circulating cells of hematopoietic origin can differentiate into vascular endothelial cells (ECs) in areas of vascular remodeling has recently gained credibility. However, no quantitative data have placed the magnitude of this contribution into a physiological perspective. We have used hematopoietic chimeras to determine that 0.2% to 1.4% of ECs in vessels in control tissues derived from hematopoietic progenitors during the4 months after irradiation and hematopoietic recovery. By contrast, 8.3% to 11.2% of ECs in vessels that developed in sponge-induced granulation tissue during 1 month derived from circulating hematopoietic progenitors. This recruitment of circulating progenitors to newly forming vessels would be difficult to observe in standard histological studies, but it is large enoughto be encouraging for attempts to manipulate this contribution for therapeutic gain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:48:49