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Titolo:
Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus andincident myocardial infarction and coronary heart disease death in older adults - The Cardiovascular Health Study
Autore:
Siscovick, DS; Schwartz, SM; Corey, L; Grayston, JT; Ashley, R; Wang, SP; Psaty, BM; Tracy, RP; Kuller, LH; Kronmal, RA;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Epidemiol, Seattle, WA USA Univ Washington Seattle WA USA shington, Dept Epidemiol, Seattle, WA USA Univ Washington, Dept Hlth Serv, Seattle, WA USA Univ Washington Seattle WA USA shington, Dept Hlth Serv, Seattle, WA USA Univ Washington, Dept Pathobiol, Seattle, WA USA Univ Washington Seattle WA USA shington, Dept Pathobiol, Seattle, WA USA Univ Washington, Dept Biostat, Seattle, WA USA Univ Washington Seattle WAUSA Washington, Dept Biostat, Seattle, WA USA Univ Washington, Dept Lab Med, Seattle, WA USA Univ Washington Seattle WAUSA Washington, Dept Lab Med, Seattle, WA USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 idemiol, Pittsburgh, PA 15261 USA Univ Vermont, Dept Pathol, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 ept Pathol, Burlington, VT 05405 USA
Titolo Testata:
CIRCULATION
fascicolo: 19, volume: 102, anno: 2000,
pagine: 2335 - 2340
SICI:
0009-7322(20001107)102:19<2335:CPHSVT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROSIS; INFECTION; RISK; ASSOCIATION; ANTIBODY; TWAR; ARTERIES;
Keywords:
bacteria; viruses; myocardial infarction; coronary heart disease; aging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Siscovick, DS Cardiovasc Hlth Res Unit, 1730 Minor Ave,Suite 1360, Seattle, WA 98101 USA Cardiovasc Hlth Res Unit 1730 Minor Ave,Suite 1360 Seattle WA USA 98101
Citazione:
D.S. Siscovick et al., "Chlamydia pneumoniae, herpes simplex virus type 1, and cytomegalovirus andincident myocardial infarction and coronary heart disease death in older adults - The Cardiovascular Health Study", CIRCULATION, 102(19), 2000, pp. 2335-2340

Abstract

Background-Whether serological evidence of prior infection with Chlamydia pneumoniae, herpes simplex virus type 1 (HSV-1), and cytomegalovirus (CMV) is associated with myocardial infarction (MI) and coronary heart disease (CHD) death remains a source of controversy. Methods and Results-We conducted a nested case-control study among participants in the Cardiovascular Health Study, a cohort study of persons aged greater than or equal to 65 years. Cases experienced an incident MI and CHD death (n=213). Control subjects were matched to cases by age, sex, clinic, year of enrollment, and month of blood draw (n=405). Serum was analyzed for IgG antibodies to C pneumoniae, HSV-1, and CMV. After adjustment for other risk factors, the risk of MI and CHD death was associated with the presenceof IgG antibodies to HSV-1 (odds ratio [OR] 2.0, 95% CI 1.1 to 3.6) but was not associated with the presence of IgG antibodies to either C pneumoniae(OR 1.1, 95% CI 0.7 to 1.8) or CMV (OR 1.2, 95% CI 0.7 to 1.9). Although there was little association with low to moderate C pneumoniae antibody titers (less than or equal to1:512), high-titer (1:1024) C pneumoniae antibody was associated with an increased risk (OR 2.2, 95% CI 1.1 to 4.4). Conclusions-Among older adults, the presence of IgG antibodies to HSV-1 was associated with a 2-fold increase in the risk of incident MI and CHD death. For C pneumoniae, only high-titer IgG antibodies were associated with anincreased risk of MI and CHD death. The presence of IgG antibodies to CMV was not associated with risk among the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:09:14