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Titolo:
Reciprocal translocation (3;5)(q26;q22) and possible BCHE gene involvementin an unusual myelogenous disorder with bath myeloproliferative and dysplastic features
Autore:
Fureder, W; Streubel, B; Jordan, JH; Walchshofer, S; Wimazal, F; Jager, U; Geissler, K; Schwartz, LB; Chott, A; Lechner, K; Valent, P; Fonatsch, C;
Indirizzi:
Univ Vienna, Dept Internal Med 1, AKH, Div Hematol & Hemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & Hemostaseol, A-1090 Vienna, Austria Univ Vienna, Inst Med Biol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Inst Med Biol, Vienna, Austria Univ Vienna, Dept Clin Pathol, Vienna, Austria Univ Vienna Vienna Austria iv Vienna, Dept Clin Pathol, Vienna, Austria Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
CANCER GENETICS AND CYTOGENETICS
fascicolo: 2, volume: 121, anno: 2000,
pagine: 133 - 138
SICI:
0165-4608(200009)121:2<133:RT(APB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELODYSPLASTIC SYNDROMES; TISSUE-SECTIONS; CLASSIFICATION; KARYOTYPE; LEUKEMIA; MORPHOLOGY; PROPOSALS; CELLS; MDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Fureder, W Univ Vienna, Dept Internal Med 1, AKH, Div Hematol & Hemostaseol, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 ria
Citazione:
W. Fureder et al., "Reciprocal translocation (3;5)(q26;q22) and possible BCHE gene involvementin an unusual myelogenous disorder with bath myeloproliferative and dysplastic features", CANC GENET, 121(2), 2000, pp. 133-138

Abstract

We report on a 77-year-old male patient who presented with an unusual myelogenous disorder exhibiting both myeloproliferative and dysplastic features. The patient suffered from leukocytosis, eosinophilia, basophilia, transfusion dependent anemia, and rapidly progressing thrombocytopenia. Classical chromosome analysis and fluorescence in situ hybridization (FISH) revealed a reciprocal t(3;5)(q26;q22). Using yeast artificial chromosome (YAC) probes, the breakpoint on chromosome 3 was localized to the butyrylcholinesterase (BCHE) gene (3q26.1-q26.2). This gene has recently been implicated in theregulation of myeloid cells. Whether the BCHE gene was also involved in the deregulation of myelopoiesis, causing the unusual clinical picture in this case, remains unknown. (C) 2000 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 22:25:53