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Titolo:
Mecamylamine but not the alpha 7 receptor antagonist alpha-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine
Autore:
Kempsill, FEJ; Pratt, JA;
Indirizzi:
Univ Strathclyde, Dept Physiol & Pharmacol, Strathclyde Inst Biomed Sci, Glasgow G4 0NR, Lanark, Scotland Univ Strathclyde Glasgow Lanark Scotland G4 0NR G4 0NR, Lanark, Scotland
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 131, anno: 2000,
pagine: 997 - 1003
SICI:
0007-1188(200011)131:5<997:MBNTA7>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC TRANSMISSION; ACETYLCHOLINE-RECEPTORS; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; TIME COURSE; RAT; BINDING; METHYLLYCACONITINE; ISOARECOLONE; INFUSION;
Keywords:
nicotine; locomotor activity; sensitization; autoradiography; alpha-bungarotoxin; alpha 7 receptors; mecamylamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pratt, JA Univ Strathclyde, Dept Physiol & Pharmacol, Strathclyde Inst Biomed Sci, Taylor St, Glasgow G4 0NR, Lanark, Scotland Univ Strathclyde Taylor St Glasgow Lanark Scotland G4 0NR otland
Citazione:
F.E.J. Kempsill e J.A. Pratt, "Mecamylamine but not the alpha 7 receptor antagonist alpha-bungarotoxin blocks sensitization to the locomotor stimulant effects of nicotine", BR J PHARM, 131(5), 2000, pp. 997-1003

Abstract

1 The involvement of alpha7 receptors in the locomotor stimulant effects of nicotine has been examined by determining the ability of intracerebroventricular (i.c.v.) administration of the alpha7 receptor antagonist alpha -bungarotoxin (alpha -bgt) to modify sensitization to the locomotor activatingeffects of chronic nicotine.2 Intracerebroventricular administration of alpha -bgt (0.02-8 nmoles) produced a dose dependent increase in convulsive behaviour. At doses less than1.0 nmole, minimal convulsive behaviour occurred but larger doses evoked convulsions in all rats which displayed a more rapid onset time as the dose increased.3 The binding distribution of alpha7 receptors 20 min and 3 h following ani.c.v. administration of [I-125]-alpha -bgt (0.02 nmoles) revealed clear binding in the hippocampus, cingulate cortex and hypothalamus which was moreintense after 3 h.4 Rats chronically treated with nicotine (0.4 mg kg(-1)) and exposed to the locomotor activity apparatus daily acquired an increase in locomotor activity relative to the control group after 3 days of treatment which reached a maximum after 7 days of treatment and was maintained for the 2 week treatment period.5 Pre-treatment with mecamylamine (1 mg kg(-1)) prevented the expression of the locomotor stimulant effects of nicotine but pre-treatment with i.c.v.alpha -bgt (0.02 nmoles) did not affect nicotine-induced changes in locomotor activity.6 The results of this study support the conclusion that nicotinic receptors of the alpha4 beta2 subtype rather than the alpha7 subtype are important in mediating the expression of the locomotor stimulant effects of nicotine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:19:29