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Titolo:
Principles of gene therapy: potential applications in the treatment of cerebral ischaemia
Autore:
Papadopoulos, MC; Giffard, RG; Bell, BA;
Indirizzi:
Univ London, St Georges Med Sch, Atkinson Morleys Hosp, Dept Neurosurg, London SW20 0NE, England Univ London London England SW20 0NE Neurosurg, London SW20 0NE, England Stanford Univ, Med Ctr, Dept Anesthesia, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 pt Anesthesia, Stanford, CA 94305 USA Stanford Univ, Med Ctr, Program Neurosci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 gram Neurosci, Stanford, CA 94305 USA
Titolo Testata:
BRITISH JOURNAL OF NEUROSURGERY
fascicolo: 5, volume: 14, anno: 2000,
pagine: 407 - 414
SICI:
0268-8697(200010)14:5<407:POGTPA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; SIMPLEX VIRUS VECTORS; FIBROBLASTS PRODUCING NGF; OXIDE SYNTHASE GENE; IN-VIVO; RAT-BRAIN; SUBARACHNOID HEMORRHAGE; NEUROLOGICAL DISORDERS; MOLECULAR NEUROSURGERY; STABLE TRANSDUCTION;
Keywords:
antisense; cerebral ischaemia; liposome; neural implant; transfection; viral vector;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Papadopoulos, MC Univ London, St Georges Med Sch, Atkinson Morleys Hosp, Dept Neurosurg, Copse Hill, London SW20 0NE, England Univ London Copse Hill London England SW20 0NE , England
Citazione:
M.C. Papadopoulos et al., "Principles of gene therapy: potential applications in the treatment of cerebral ischaemia", BR J NEUROS, 14(5), 2000, pp. 407-414

Abstract

In this review we explore gene therapy as a possible treatment for conditions causing cerebral ischaemia and briefly consider other neurological pathologies such as brain tumours. DNA transfer may be achieved using retrovirus, herpes simplex virus, adenovirus, and adeno-associated virus vectors or liposomes. After cerebral ischaemia, these vectors are used to upregulate genes that increase survival and inhibit those that promote death in the injured cells. In contrast, in brain tumours gene therapy aims to kill the target cells. Examples from studies using cell culture, animal models and patients are presented. We conclude that manipulation of gene expression has potential for the treatment of cerebral ischaemia and brain tumours, although, at present, there are formidable technical obstacles to be overcome before clinical applications become a reality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:10:33