Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis
Autore:
Bouffler, SD; Hofland, N; Cox, R; Fodde, R;
Indirizzi:
Natl Radiol Protect Board, Radiat Effects Dept, Didcot OX11 0RQ, Oxon, England Natl Radiol Protect Board Didcot Oxon England OX11 0RQ 0RQ, Oxon, England Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2300 RA Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RA NL-2300 RA Leiden, Netherlands
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 10, volume: 83, anno: 2000,
pagine: 1291 - 1294
SICI:
0007-0920(200011)83:10<1291:EFMHIM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; MISMATCH REPAIR DEFICIENCY; IONIZING-RADIATION; MSH2-DEFICIENT MICE; MUTATIONS; MOUSE; CELLS; GENE; HYPERMUTABILITY; SENSITIVITY;
Keywords:
Msh2; mismatch repair; alkylating agent; ionizing radiation; sister-chromatid exchange;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bouffler, SD Natl Radiol Protect Board, Radiat Effects Dept, Didcot OX11 0RQ, Oxon, England Natl Radiol Protect Board Didcot Oxon England OX11 0RQ gland
Citazione:
S.D. Bouffler et al., "Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis", BR J CANC, 83(10), 2000, pp. 1291-1294

Abstract

The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC, Msh2 Delta 7N. Chromosome aberration frequencies were similar in bone marrow of Msh2(+/+), Msh2(+/-) and Msh2(-/-) mice and no differential effects of in vivo X-irradiation were noted. By contrast, the induction of sister-chromatid exchanges (SCEs) by methyl nitrosourea (MNU) was reduced in Msh2(-/-) and Msh2(+/-) cells to similar to 20% and similar to 45% wild-type levels respectively indicating a phenotypic effect of haploinsufficiency of the mouse Msh2 gene. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:17:53