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Titolo:
Cortical cholinergic activity is related to the novelty of the stimulus
Autore:
Miranda, MI; Ramirez-Lugo, L; Bermudez-Rattoni, F;
Indirizzi:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, MexicoCity 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 882, anno: 2000,
pagine: 230 - 235
SICI:
0006-8993(20001103)882:1-2<230:CCAIRT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONED TASTE-AVERSION; ENHANCED ACETYLCHOLINE-RELEASE; FETAL NEOCORTEX GRAFTS; RAT INSULAR CORTEX; EXTRACELLULAR ACETYLCHOLINE; HIPPOCAMPAL ACETYLCHOLINE; TYROSINE PHOSPHORYLATION; COGNITIVE FUNCTIONS; NUCLEUS BASALIS; HABITUATION;
Keywords:
acetylcholine; rat free-moving microdialysis; gustatory cortex; cholinergic basal forebrain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bermudez-Rattoni, F Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, MexicoCity 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510
Citazione:
M.I. Miranda et al., "Cortical cholinergic activity is related to the novelty of the stimulus", BRAIN RES, 882(1-2), 2000, pp. 230-235

Abstract

A number of studies have related cholinergic activity to the mediation of learning and memory. However, the acetylcholine (ACh) participation has been recently implicated in the early stages of memory formation but not during retrieval. The aim of the present study is to evaluate ACh release in theinsular cortex (IC) during presentation of different taste stimuli and during their re-exposition by means of the free-moving microdialysis technique. We evaluated the changes in ACh release when a novel taste, saccharin or quinine was presented to the rat and after several presentations of saccharin. Unilateral microdialysis was performed in the IC 1 h before and 1 h after the presentation of: (1) a familiar stimulus (water), (2) a novel taste (quinine), (3) another novel taste (saccharin), (4) a second presentation, (5) a third presentation, and (6) a fourth presentation of saccharin. The volume consumed by the animals wets registered as a behavioral parameter. The ACh levels from the microdialysis fractions were analyzed by an HPLC-ED system. Biochemical results showed a significant increment in the cortical ACh release induced by a novel stimulus compared with the release observed during the presentation of a familiar stimulus. The ACh release observed after several presentations of the stimuli decreased to the same levels as those produced by the familiar taste, indicating an inverse relationship between familiarity and cortical ACh release. These results suggest that the cholinergic system plays an important role in the identification and characterization of different kinds of stimuli. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:27:48