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Titolo:
Crucial role of kainate receptors in mediating striatal kainate injection-induced decrease in acetylcholine M-1 receptor binding in rat forebrain
Autore:
Jin, S; Yang, J; Lee, WL; Wong, PTH;
Indirizzi:
Natl Univ Singapore, Fac Med, Dept Pharmacol, Singapore 117597, Singapore Natl Univ Singapore Singapore Singapore 117597 ngapore 117597, Singapore Natl Neurosci Inst Singapore, Singapore 308433, Singapore Natl Neurosci Inst Singapore Singapore Singapore 308433 08433, Singapore
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 882, anno: 2000,
pagine: 128 - 138
SICI:
0006-8993(20001103)882:1-2<128:CROKRI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL MOSSY FIBERS; GLUTAMATE RECEPTORS; AMPA-RECEPTOR; NMDA RECEPTOR; KAINIC ACID; DOMOIC ACID; ALZHEIMERS-DISEASE; NERVOUS-SYSTEM; RELEASE; LOCALIZATION;
Keywords:
cholinergic neurotransmission; CNQX; cyclothiazide; kainate injection; [H-3]pirenzepine binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, S Natl Univ Singapore, Fac Med, Dept Pharmacol, MD2,18 Med Dr, Singapore 117597, Singapore Natl Univ Singapore MD2,18 Med Dr Singapore Singapore 117597 apore
Citazione:
S. Jin et al., "Crucial role of kainate receptors in mediating striatal kainate injection-induced decrease in acetylcholine M-1 receptor binding in rat forebrain", BRAIN RES, 882(1-2), 2000, pp. 128-138

Abstract

We investigated the roles of kainate-, alpha -amino-3-hydroxy-5-methylisoxazol-4-propionate (AMPA)- and N-methyl-D-aspartate (NMDA)-receptors in mediating striatal kainate injection-induced decrease in the binding of acetylcholine M-1 receptors in rat forebrain. After unilateral intrastriatal injection of kainate (4 nmol), the bindings of [H-3]kainate (10 nM), [H-3]MK-801(4 nM) and [H-3]pirenzepine (4 nM) to the rat ipsilateral forebrain membranes declined, reaching the lowest on day 2 to 4 and recovering on day 8. Saturation binding studies, performed on day 2 post-injection, showed that kainate (1, 2, 4 nmol) dose-dependently decreased B-max and K-d of the three ligands. (+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), a selective NMDA receptor channel blocker, antagonised (from a dose of 4 nmol) kainate-induced decreases in the bindings of [H-3]kainate (up to similar to 20%), [H-3]MK-801 (up to similar to 90%) and [H-3]pirenzepine(up to similar to 70%). In contrast, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a selective non-NMDA receptor antagonist, almost completely abolished (from a dose of 12 nmol) kainate-induced decreases in the bindings of all the three ligands (up to similar to 95-98%). Cyclothiazide, a selective potentiator that enhances AMPA receptor-mediated responses, significantly enhanced (from a dose of 4 nmol) kainate-induced decrease in the binding of [H-3]kainate but not that of [H-3]pirenzepine or [H-3]MK-801. In summary, these results indicate that striatal kainate injection-induced decrease in the binding of acetylcholine M-1 receptors in rat forebrain is dependent on activation of kainate receptors and, to a certain extent, a consequent involvement of NMDA receptors. These and previous studies provide some evidence showing that kainate receptors might play a crucial role in regulating excitatory amino acids (EAA)-modulated cholinergic neurotransmission in the central nervous system (CNS). (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 11/07/20 alle ore 07:49:57